Description

2-Chloro-4-methyl-3-nitropyridine (CAS No. 23056-39-5) is a high-purity heterocyclic compound with the molecular formula C₆H₅ClN₂O₂. This nitropyridine derivative is an essential intermediate in organic synthesis and pharmaceutical research, offering exceptional reactivity for nucleophilic substitution and reduction reactions. Its unique structure, featuring a chloro group at the 2-position and a nitro group at the 3-position, makes it a versatile building block for synthesizing complex molecules. Ideal for researchers in medicinal chemistry, agrochemicals, and material science, this compound is supplied with comprehensive analytical data (including ¹H NMR, HPLC, and GC-MS) to ensure quality and reproducibility. Store in a cool, dry place under inert conditions to maintain stability.

Properties

• CAS Number: 23056-39-5
• Complexity: 159
• IUPAC Name: 2-chloro-4-methyl-3-nitro-pyridine
• InChI: InChI=1S/C6H5ClN2O2/c1-4-2-3-8-6(7)5(4)9(10)11/h2-3H,1H3
• InChI Key: JHARVUVBTAAPLA-UHFFFAOYSA-N
• Exact Mass: 172.0039551
• Molecular Formula: C6H5ClN2O2
• Molecular Weight: 172.57
• SMILES: CC1=C(C(=NC=C1)Cl)[N+](=O)[O-]
• Topological: 58.7
• Monoisotopic Mass: 172.0039551
• Synonyms: 2-Chloro-4-methyl-3-nitropyridine, 23056-39-5, DTXSID30323072, DTXCID30274191, 607-192-0, 2-Chloro-3-nitro-4-picoline, Pyridine, 2-chloro-4-methyl-3-nitro-, 2-Chloro-3-nitro-4-methylpyridine, MFCD00012347, 2-Chloro-3-nitro-4-picoline; 2-Chloro-3-nitro-4-methylpyridine; NSC 402977;, NSC402977, 2-Chloro-3-nitro4-picoline, SCHEMBL541578, 2-Chloro-3-nitro-4-picoline (2-Chloro-4-methyl-3-nitropyridine), BCP07287, 2-chloro-4-methyl-3-nitro pyridine, SBB054324, AKOS005145616, AC-5434, CS-W020672, FC20099, NSC 402977, NSC-402977, PB12972, PS-4628, HY-32806, SY008500, 2-Chloro-4-methyl-3-nitropyridine, 99%, DB-005221, C2012, NS00122518, EN300-77834

Application

2-Chloro-4-methyl-3-nitropyridine is widely used as a key intermediate in the synthesis of pharmaceuticals, particularly for antimalarial and antiviral agents. Its reactive chloro and nitro groups facilitate further functionalization, enabling the construction of pyridine-based scaffolds. Researchers also employ it in agrochemical development and as a precursor for ligands in catalysis. Its stability and selectivity make it valuable for exploratory organic synthesis.

Safety and Hazards

GHS Hazard Statements

• H302 (10.6%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (10.6%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.