Description

2-Chloro-4-fluorotoluene (CAS No. 452-73-3) is a high-purity organic compound with the molecular formula C₇H₆ClF. This halogenated toluene derivative is widely utilized in pharmaceutical, agrochemical, and material science research due to its versatile reactivity as a building block. With a purity of ≥99%, our product is rigorously tested via GC, NMR, and HPLC to ensure compliance with industry standards. Ideal for nucleophilic substitutions, cross-coupling reactions (e.g., Suzuki, Heck), and as a precursor for fluorinated intermediates. Packaged under inert gas in amber glass vials to prevent degradation. SDS and Certificates of Analysis (CoA) available upon request.

Properties

• CAS Number: 452-73-3
• Complexity: 94.9
• IUPAC Name: 2-chloro-4-fluoro-1-methyl-benzene
• InChI: InChI=1S/C7H6ClF/c1-5-2-3-6(9)4-7(5)8/h2-4H,1H3
• InChI Key: CSARJIQZOSVYHA-UHFFFAOYSA-N
• Exact Mass: 144.0142060
• Molecular Formula: C7H6ClF
• Molecular Weight: 144.57
• SMILES: CC1=C(C=C(C=C1)F)Cl
• Monoisotopic Mass: 144.0142060
• Synonyms: 2-Chloro-4-fluorotoluene, 452-73-3, 2-Chloro-4-fluoro-1-methylbenzene, Benzene, 2-chloro-4-fluoro-1-methyl-, 4-fluoro-2-chlorotoluene, GP4EY2J3GP, EINECS 207-209-8, NSC-88317, DTXSID50196427, NSC 88317, TOLUENE, 2-CHLORO-4-FLUORO-, DTXCID60118918, 207-209-8, 2-Chloro-4-fluorotolueneC, MFCD00000572, NSC88317, 2-chloro-4fluorotoluene, 4-Fluor-2-chlor-toluol, UNII-GP4EY2J3GP, SCHEMBL254861, SCHEMBL260518, SCHEMBL314652, SCHEMBL2345911, SCHEMBL2347078, SCHEMBL4654503, CSARJIQZOSVYHA-UHFFFAOYSA-, 2-Chloro-4-fluorotoluene, 99%, SBB086382, 2-Chloro-4-fluoro-1-methylbenzene #, AKOS005063641, AC-9818, FC34271, AS-12614, DB-024062, C1227, CS-0010402, NS00042958, EN300-21356, D72489, InChI=1/C7H6ClF/c1-5-2-3-6(9)4-7(5)8/h2-4H,1H3, 2-Chloro-4-fluorotoluene, TraceCERT(R), certified reference material, 19F-qNMR Standard

2-Chloro-4-fluorotoluene serves as a key intermediate in synthesizing active pharmaceutical ingredients (APIs) and liquid crystal materials. Its chloro and fluoro substituents enable selective functionalization for agrochemicals like herbicides and pesticides. Researchers also employ it in palladium-catalyzed coupling reactions to construct complex fluorinated aromatic systems. Suitable for small-scale R&D and bulk manufacturing under controlled conditions.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (97.8%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Skin Irrit. 2 (97.8%)
• Eye Irrit. 2 (97.8%)
• STOT SE 3 (95.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.