Description

2-Chloro-4-fluoropyridine (CAS No. 34941-91-8) is a high-purity halogenated pyridine derivative, widely utilized in pharmaceutical and agrochemical research as a versatile building block for heterocyclic synthesis. With the molecular formula C₅H₃ClFN, this compound exhibits excellent reactivity due to the presence of both chloro and fluoro substituents on the pyridine ring, enabling selective functionalization via nucleophilic aromatic substitution (S_NAr) or cross-coupling reactions. Available in ≥98% purity (GC), it is supplied as a clear, colorless to pale-yellow liquid with a characteristic pyridine odor, packaged under inert gas to ensure stability. Ideal for medicinal chemistry, material science, and catalysis applications, this reagent is rigorously tested for impurities (HPLC, NMR) and stored under controlled conditions to maintain optimal performance. Compatible with Grignard reagents, lithiation, and Pd-catalyzed transformations.

Properties

• CAS Number: 34941-91-8
• Complexity: 78.8
• IUPAC Name: 2-chloro-4-fluoro-pyridine
• InChI: InChI=1S/C5H3ClFN/c6-5-3-4(7)1-2-8-5/h1-3H
• InChI Key: FGSAQRJRWCZLOB-UHFFFAOYSA-N
• Exact Mass: 130.9938050
• Molecular Formula: C5H3ClFN
• Molecular Weight: 131.53
• SMILES: C1=CN=C(C=C1F)Cl
• Topological: 12.9
• Monoisotopic Mass: 130.9938050
• Synonyms: 2-Chloro-4-fluoropyridine, 34941-91-8, DTXSID20382299, DTXCID40333324, 675-788-8, MFCD04039345, PYRIDINE, 2-CHLORO-4-FLUORO-, 2-Chloro-4-fluoro-pyridine, SCHEMBL45510, SCHEMBL1045263, SCHEMBL4927350, SCHEMBL7757964, BCP05875, SBB013977, STK664296, AKOS005064105, 2-Chloro-4-fluoropyridine, AldrichCPR, AB17349, AS-8192, CS-W007987, AC-10871, DB-011989, ST4128533, C2627, EN300-93196

2-Chloro-4-fluoropyridine serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral and anticancer agents. Its dual halogenation allows selective derivatization to create novel pyridine-based scaffolds in drug discovery. In agrochemical research, it is employed to develop advanced crop protection compounds with enhanced bioactivity. The compound also finds use in materials science for constructing functionalized ligands in coordination chemistry.

Safety and Hazards

GHS Hazard Statements

• H226 (97.9%): Flammable liquid and vapor [Warning Flammable liquids]
• H302+H312+H332 (83.3%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H302 (89.6%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (87.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (12.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (87.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (83.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (97.9%)
• Acute Tox. 4 (89.6%)
• Acute Tox. 4 (87.5%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (12.5%)
• Eye Irrit. 2 (87.5%)
• Acute Tox. 4 (83.3%)
• STOT SE 3 (97.9%)

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