Description

2-Chloro-4-fluorophenol (CAS No. 1996-41-4) is a halogenated phenol derivative with the molecular formula C₆H₄ClFO. This high-purity compound is a valuable building block in organic synthesis, particularly in pharmaceutical and agrochemical research. The presence of both chloro and fluoro substituents on the phenolic ring enhances its reactivity, making it a versatile intermediate for nucleophilic aromatic substitution and cross-coupling reactions.

Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied as a clear to pale yellow liquid with a characteristic phenolic odor. It is packaged under inert gas to maintain stability and shipped with comprehensive analytical data, including ¹H NMR, ¹³C NMR, and GC-MS spectra. Suitable for use in GMP environments when specified.

Storage: Store at 2-8°C in a tightly sealed container under inert atmosphere. Handling: Use in well-ventilated areas with appropriate PPE due to potential toxicity and irritant properties.

Properties

• CAS Number: 1996-41-4
• Complexity: 99.1
• IUPAC Name: 2-chloro-4-fluoro-phenol
• InChI: InChI=1S/C6H4ClFO/c7-5-3-4(8)1-2-6(5)9/h1-3,9H
• InChI Key: IGYXYGDEYHNFFT-UHFFFAOYSA-N
• Exact Mass: 145.9934706
• Molecular Formula: C6H4ClFO
• Molecular Weight: 146.54
• SMILES: C1=CC(=C(C=C1F)Cl)O
• Topological: 20.2
• Monoisotopic Mass: 145.9934706
• Synonyms: 2-CHLORO-4-FLUOROPHENOL, 1996-41-4, Phenol, 2-chloro-4-fluoro-, EINECS 217-876-7, NSC 10273, DTXSID60173744, DTXCID4096235, Phenol, 2-chloro-4-fluoro-(8CI), Phenol, 2-chloro-4-fluoro-(8CI)(9CI), 217-876-7, igyxygdeyhnfft-uhfffaoysa-n, inchi=1/c6h4clfo/c7-5-3-4(8)1-2-6(5)9/h1-3,9, 2-chloro-4-fluoro-phenol, MFCD00002168, NSC-10273, 2-chlor-4-fluorophenol, 4-fluoro-2-chlorophenol, NSC10273, KZ55A7Y5ER, SCHEMBL104856, SCHEMBL717089, SCHEMBL1638801, SCHEMBL2851087, SCHEMBL27446051, 1-Bromo-2,3,5-trifluorobezene, 2-Chloro-4-fluorophenol, 99%, SBB086515, AKOS000119579, AC-5937, CS-W007676, PS-8942, SY008843, DB-023804, C1598, NS00026490, ST50824048, EN300-21349, A19902, Z104495502

Application

2-Chloro-4-fluorophenol serves as a key intermediate in the synthesis of advanced pharmaceutical compounds, particularly in the development of antimicrobial and antifungal agents. Its unique substitution pattern makes it valuable for creating heterocyclic compounds through palladium-catalyzed coupling reactions. Researchers also utilize this chemical in material science for modifying polymer properties and in agrochemical research for developing novel pesticides.

Safety and Hazards

GHS Hazard Statements

• H302 (12.5%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (12.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (89.6%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (87.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (85.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (12.5%)
• Acute Tox. 4 (12.5%)
• Skin Irrit. 2 (89.6%)
• Eye Irrit. 2 (87.5%)
• STOT SE 3 (85.4%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.