Description

2-Chloro-4-fluorobenzaldehyde (CAS No. 84194-36-5) is a high-purity aromatic aldehyde featuring both chloro and fluoro substituents, making it a versatile intermediate in organic synthesis and pharmaceutical research. With the molecular formula C₇H₄ClFO, this compound is characterized by its distinct reactivity due to the presence of electron-withdrawing groups, which enhance its utility in cross-coupling reactions, nucleophilic substitutions, and as a precursor for heterocyclic compounds. Available in >98% purity (GC), it is supplied as a clear to pale-yellow crystalline solid with strict quality control to ensure consistency for sensitive applications. Ideal for use in medicinal chemistry, agrochemical development, and material science, this reagent is packaged under inert conditions to guarantee stability and longevity. Store in a cool, dry place away from light and moisture to maintain optimal performance.

Properties

• CAS Number: 84194-36-5
• Complexity: 129
• IUPAC Name: 2-chloro-4-fluoro-benzaldehyde
• InChI: InChI=1S/C7H4ClFO/c8-7-3-6(9)2-1-5(7)4-10/h1-4H
• InChI Key: KMQWNQKESAHDKD-UHFFFAOYSA-N
• Exact Mass: 157.9934706
• Molecular Formula: C7H4ClFO
• Molecular Weight: 158.56
• SMILES: C1=CC(=C(C=C1F)Cl)C=O
• Topological: 17.1
• Monoisotopic Mass: 157.9934706
• Synonyms: 2-Chloro-4-fluorobenzaldehyde, 84194-36-5, DTXSID10233105, DTXCID70155596, 617-548-7, MFCD00042527, 4-fluoro-2-chlorobenzaldehyde, Benzaldehyde, 2-chloro-4-fluoro-, 2-chloro-4-fluoro-benzaldehyde, SCHEMBL96822, SCHEMBL96823, 2-chloro-4-fluorobezaldehyde, 2-chloro 4-fluorobenzaldehyde, 2-chloro 4-fluoro benzaldehyde, SCHEMBL27337550, BCP29326, 2-chloranyl-4-fluoranyl-benzaldehyde, BBL020342, SBB003983, STK891549, 2-Chloro-4-fluorobenzaldehyde, 97%, AKOS005144254, AC-2503, CS-W007440, FC03941, PS-8798, SY001687, DB-024262, NS00122899, ST50824718, EN300-71424, A840735, F0001-2139, Z1079442562, 2-Chloro-4-fluoro-benzaldehyde;4-Fluoro-2-chlorobenzaldehyde, InChI=1/C7H4ClFO/c8-7-3-6(9)2-1-5(7)4-10/h1-4

Application

2-Chloro-4-fluorobenzaldehyde is widely employed as a key building block in the synthesis of pharmaceuticals, particularly for antiretroviral and anticancer agents, due to its halogenated aromatic structure. It serves as a precursor in the preparation of Schiff bases and other derivatives used in ligand design and catalysis. Additionally, this compound finds applications in agrochemical research for developing novel pesticides and herbicides with enhanced efficacy.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.