Description

2-Chloro-4-fluoroanisole (CAS No. 2267-25-6) is a high-purity fluorinated aromatic compound with the molecular formula C₇H₆ClFO. This versatile intermediate features a chloro-fluoro substitution pattern on a methoxybenzene backbone, making it a valuable building block for pharmaceutical, agrochemical, and materials science applications. The compound is supplied as a clear, colorless to pale yellow liquid with ≥98% purity (GC), packaged under inert atmosphere to ensure stability. Its unique electronic properties derived from the halogen and methoxy substituents make it particularly useful in cross-coupling reactions and as a precursor for advanced heterocyclic systems. Strict quality control ensures batch-to-batch consistency for research and production needs.

Properties

• CAS Number: 2267-25-6
• Complexity: 110
• IUPAC Name: 2-chloro-4-fluoro-1-methoxy-benzene
• InChI: InChI=1S/C7H6ClFO/c1-10-7-3-2-5(9)4-6(7)8/h2-4H,1H3
• InChI Key: RKCGJVGMRPKPNY-UHFFFAOYSA-N
• Exact Mass: 160.0091207
• Molecular Formula: C7H6ClFO
• Molecular Weight: 160.57
• SMILES: COC1=C(C=C(C=C1)F)Cl
• Topological: 9.2
• Monoisotopic Mass: 160.0091207
• Synonyms: 2-Chloro-4-fluoroanisole, 2267-25-6, 2-chloro-4-fluoro-1-methoxybenzene, DTXSID60378570, DTXCID10329597, 607-127-6, MFCD00672965, Benzene, 2-chloro-4-fluoro-1-methoxy-, 2-CHLORO-4-FLUORO-1-METHOXY-BENZENE, SCHEMBL718547, Anisole, 2-chloro-4-fluoro-, SCHEMBL1684131, SCHEMBL1761774, SCHEMBL2249460, SCHEMBL2342052, 2-Chloro-4-fluoroanisole, 97%, SBB087483, AKOS006223895, AC-3770, CS-W016148, JS-4296, SY049455, DB-013047, C1667, NS00125019, ST50407494, EN300-1241647

Application

2-Chloro-4-fluoroanisole serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates. The compound is utilized in palladium-catalyzed cross-coupling reactions to construct complex aromatic systems in medicinal chemistry. Its electron-deficient aromatic ring makes it valuable for developing agrochemicals such as herbicides and pesticides. Researchers also employ this chemical as a building block for liquid crystals and specialty polymers.

Safety and Hazards

GHS Hazard Statements

• H315 (97.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (97.9%)
• Eye Irrit. 2 (97.9%)
• STOT SE 3 (95.7%)

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