Description

2-Chloro-3-pyridylamine (CAS No. 6298-19-7) is a high-purity organic compound with the molecular formula C₅H₅ClN₂, widely utilized in pharmaceutical and agrochemical research. This compound, also known by its IUPAC name 2-chloropyridin-3-amine, features a chlorinated pyridine ring with an amine group at the 3-position, making it a versatile intermediate for heterocyclic synthesis. Our product is rigorously tested to ensure ≥98% purity (HPLC/GC) and is supplied as a fine crystalline powder with excellent solubility in common organic solvents like DMSO, ethanol, and dichloromethane. Ideal for cross-coupling reactions, functional group transformations, and as a precursor for bioactive molecules, this compound is packaged under inert conditions to guarantee stability and longevity. Each batch is accompanied by comprehensive analytical data, including ¹H NMR, ¹³C NMR, and mass spectrometry reports.

Properties

• CAS Number: 6298-19-7
• Complexity: 76.8
• IUPAC Name: 2-chloropyridin-3-amine
• InChI: InChI=1S/C5H5ClN2/c6-5-4(7)2-1-3-8-5/h1-3H,7H2
• InChI Key: MEQBJJUWDCYIAB-UHFFFAOYSA-N
• Exact Mass: 128.0141259
• Molecular Formula: C5H5ClN2
• Molecular Weight: 128.56
• SMILES: C1=CC(=C(N=C1)Cl)N
• Topological: 38.9
• Monoisotopic Mass: 128.0141259
• Synonyms: 3-Amino-2-chloropyridine, 6298-19-7, 2-Chloro-3-aminopyridine, 3-Pyridinamine, 2-chloro-, 2-Chloro-3-pyridylamine, 2-chloropyridin-3-ylamine, WFH374WQE6, EINECS 228-572-9, NSC-45407, 2-CHLORO-3-PYRIDINEAMINE, DTXSID40212185, NSC 45407, DTXCID40134676, 228-572-9, 2-chloropyridin-3-amine, 2-Chloro-3-pyridinamine, MFCD00006238, 2-chloro-pyridin-3-ylamine, Pyridine, 3-amino-2-chloro-, 3-amino-2-chloro-pyridine, 2-Chloranylpyridin-3-Amine, Pyridine, 2-chloro-3-amino-, 2-CHLORO-3-PYRIDINYLAMINE, 2-Chloro-3-amino-pyridine, NSC45407, 2chloro-3-aminopyridine, UNII-WFH374WQE6, SCHEMBL160353, SCHEMBL2067997, SCHEMBL3516919, SCHEMBL4051565, SCHEMBL6543714, CHEMBL4639717, 3-Amino-2-chloropyridine, 98%, BCP26985, HY-Y0244, SBB004233, STK506778, AKOS000119691, AC-4662, CS-W019980, PB23167, PS-5762, SB21670, BP-21331, SY005474, DB-022191, DB-239897, A0836, NS00035236, ST50325039, EN300-19839, P16534, AC-907/25014052, SR-01000944743, SR-01000944743-1, F3284-8126, Z104475710, InChI=1/C5H5ClN2/c6-5-4(7)2-1-3-8-5/h1-3H,7H, L97

Application

2-Chloro-3-pyridylamine serves as a key building block in the synthesis of pharmaceuticals, particularly for antimalarial and antiviral agents. It is also employed in the development of herbicides and insecticides due to its pyridine-based scaffold. Researchers utilize this compound in Pd-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex heterocycles. Its amine group allows for further derivatization, enabling the creation of sulfonamides, ureas, or amides for drug discovery pipelines.

Safety and Hazards

GHS Hazard Statements

• H315 (86.5%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (86.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (84.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (86.5%)
• Eye Irrit. 2 (86.5%)
• STOT SE 3 (84.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.