Description

2-Chloro-3-pyridinol (CAS No. 6636-78-8) is a high-purity chlorinated pyridine derivative with the molecular formula C₅H₄ClNO. This compound, also known by its IUPAC name 2-chloropyridin-3-ol, is a versatile heterocyclic building block widely used in pharmaceutical, agrochemical, and material science research. The presence of both chloro and hydroxyl functional groups on the pyridine ring enables diverse chemical modifications, making it valuable for synthesizing biologically active compounds and ligands.

Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied as a fine crystalline powder with excellent batch-to-batch consistency. Special storage conditions are not required, but we recommend keeping the material in a cool, dry place under inert atmosphere for long-term stability. Available in quantities from grams to kilograms, with custom packaging options available for bulk orders.

Key applications include use as:

• Intermediate for neonicotinoid insecticide development
• Precursor for pharmaceutical active ingredients
• Ligand in coordination chemistry
• Building block for functional materials

Properties

• CAS Number: 6636-78-8
• Complexity: 78.8
• IUPAC Name: 2-chloropyridin-3-ol
• InChI: InChI=1S/C5H4ClNO/c6-5-4(8)2-1-3-7-5/h1-3,8H
• InChI Key: RSOPTYAZDFSMTN-UHFFFAOYSA-N
• Exact Mass: 128.9981414
• Molecular Formula: C5H4ClNO
• Molecular Weight: 129.54
• SMILES: C1=CC(=C(N=C1)Cl)O
• Topological: 33.1
• Monoisotopic Mass: 128.9981414
• Synonyms: 2-Chloro-3-hydroxypyridine, 6636-78-8, 2-Chloropyridin-3-ol, 2-Chloro-3-pyridinol, 3-Pyridinol, 2-chloro-, EINECS 229-635-3, NSC 18469, BRN 0002216, VY212Q0S3J, AI3-61989, NSC-18469, DTXSID3022243, RSOPTYAZDFSMTN-UHFFFAOYSA-, 3-HYDROXY-2-CHLOROPYRIDINE, 5-21-02-00085 (Beilstein Handbook Reference), DTXCID002243, inchi=1/c5h4clno/c6-5-4(8)2-1-3-7-5/h1-3,8h, MFCD00006235, UNII-VY212Q0S3J, NSC18469, 2-CHLORO-3-HYDROXY PYRIDINE, 2-chloro-pyridin-3-ol, WLN: T6NJ BG CQ, 2-chloro-3-hydroxy-pyridine, 3-Pyridinol, 2-chloro- [, SCHEMBL188902, SCHEMBL322706, 2-Chloro-3-hydroxypyridine (2-Chloro-3-pyridinol), CHEMBL4636200, 2-Chloro-3-hydroxypyridine, 98%, CS-D0978, STR03887, SBB054358, AKOS000431571, AC-4666, FC00209, PB21615, PS-4577, BP-12768, HY-32833, SY001399, DB-020787, NS00045923, EN300-80718, Q27292085, F0001-1768

Application

2-Chloro-3-pyridinol serves as a key intermediate in the synthesis of neonicotinoid insecticides, particularly in the development of chloronicotinyl compounds. In pharmaceutical research, it is utilized as a building block for creating potential drug candidates targeting neurological disorders. The compound’s bifunctional nature allows for selective modifications at either the chloro or hydroxyl positions, making it valuable for structure-activity relationship studies in medicinal chemistry.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.