Description

2-Chloro-3-nitropyridine (CAS No. 5470-18-8) is a high-purity heterocyclic compound with the molecular formula C₅H₃ClN₂O₂, widely utilized in pharmaceutical and agrochemical research. This yellow crystalline solid is characterized by its chloro and nitro functional groups at the 2- and 3-positions of the pyridine ring, respectively, making it a versatile intermediate for nucleophilic substitution and coupling reactions. With a molecular weight of 158.54 g/mol, it is soluble in organic solvents like ethanol, DMSO, and dichloromethane but exhibits limited solubility in water. Our product is rigorously tested via HPLC, GC, and NMR to ensure ≥98% purity, meeting the stringent demands of synthetic chemists. Proper storage at 2-8°C in a tightly sealed container is recommended to maintain stability.

Properties

• CAS Number: 5470-18-8
• Complexity: 136
• IUPAC Name: 2-chloro-3-nitro-pyridine
• InChI: InChI=1S/C5H3ClN2O2/c6-5-4(8(9)10)2-1-3-7-5/h1-3H
• InChI Key: UUOLETYDNTVQDY-UHFFFAOYSA-N
• Exact Mass: 157.9883050
• Molecular Formula: C5H3ClN2O2
• Molecular Weight: 158.54
• SMILES: C1=CC(=C(N=C1)Cl)[N+](=O)[O-]
• Topological: 58.7
• Monoisotopic Mass: 157.9883050
• Physical Description: Light yellow powder;
• Synonyms: 2-Chloro-3-nitropyridine, 5470-18-8, Pyridine, 2-chloro-3-nitro-, EINECS 226-799-8, NSC 26279, DTXSID2063929, 3Nitro2chloropyridine, Pyridine, 2chloro3nitro, DTXCID4041787, 226-799-8, inchi=1/c5h3cln2o2/c6-5-4(8(9)10)2-1-3-7-5/h1-3, uuoletydntvqdy-uhfffaoysa-n, 2-chloro-3-nitro-pyridine, 34515-82-7, 3-Nitro-2-chloropyridine, MFCD00006232, PYRIDINE,2-CHLORO-3-NITRO-, 2-chloro-3-nitro pyridine, NSC26279, 2-chloro-nitropyridine, 2-chloro-3nitropyridine, 2-chloro3-nitropyridine, 2-chlor-3-nitropyridine, 2-choro-3-nitro-pyridine, 3-nitro-2-chloro-pyridine, SCHEMBL75026, 2-chloranyl-3-nitro-pyridine, SCHEMBL1531049, SCHEMBL2757579, CHEMBL4641778, SCHEMBL29259432, 2-Chloro-3-nitropyridine, 98%, 2-Chloro-3-nitropyridine, 99%, BCP11394, NSC-26279, SBB054234, STK802685, AKOS000120582, AC-2560, CS-W007590, FC06225, PB33644, PS-4570, SB36737, DB-031382, A7944, NS00033178, ST51021125, EN300-18086, A822259, F0001-1442

Application

2-Chloro-3-nitropyridine serves as a key building block in the synthesis of pharmaceuticals, particularly for developing antiviral and anticancer agents. It is employed in cross-coupling reactions (e.g., Suzuki-Miyaura) to construct complex nitrogen-containing scaffolds. Additionally, its nitro group facilitates reduction to amino derivatives for further functionalization in agrochemical intermediates.

Safety and Hazards

GHS Hazard Statements

• H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
• H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Precautionary Statements

• P264, P264+P265, P270, P280, P301+P316, P305+P354+P338, P317, P321, P330, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (83.7%)
• Acute Tox. 4 (12.2%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.