Description

2-Chloro-3-methylpyridine (CAS No. 18368-76-8) is a high-purity heterocyclic organic compound with the molecular formula C₆H₆ClN. This versatile chemical intermediate is widely utilized in pharmaceutical synthesis, agrochemical production, and advanced material research. Our product is supplied as a clear to pale-yellow liquid with a minimum purity of 97%, rigorously tested by GC analysis to ensure batch-to-batch consistency. The compound features a chloro substituent at the 2-position and a methyl group at the 3-position on the pyridine ring, creating unique reactivity patterns valuable for nucleophilic substitutions and cross-coupling reactions. Proper handling requires storage under inert gas at 2-8°C in tightly sealed containers due to its moisture sensitivity. Available in research quantities (100mg to 1kg) with customizable packaging options including amber glass vials and nitrogen-flushed drums for bulk orders.

Properties

• CAS Number: 18368-76-8
• Complexity: 74.9
• IUPAC Name: 2-chloro-3-methyl-pyridine
• InChI: InChI=1S/C6H6ClN/c1-5-3-2-4-8-6(5)7/h2-4H,1H3
• InChI Key: RKVUCIFREKHYTL-UHFFFAOYSA-N
• Exact Mass: 127.0188769
• Molecular Formula: C6H6ClN
• Molecular Weight: 127.57
• SMILES: CC1=C(N=CC=C1)Cl
• Topological: 12.9
• Monoisotopic Mass: 127.0188769
• Synonyms: 2-Chloro-3-methylpyridine, 18368-76-8, EINECS 242-242-1, DTXSID00171461, DTXCID2093952, 242-242-1, 2-Chloro-3-picoline, 2-Chloro 3-methylpyridine, MFCD00234177, Pyridine, 2-chloro-3-methyl-, 3-Picoline, 2-chloro-, 2-chloro-3-methyl pyridine, 2-chloro-3-methyl-pyridine, 2-chloro-methyl-pyridine, 2-Chloro3-methylpyridine, 2-chloro3-methyl-pyridine, 2-Chloro-3-methylpyridine (2-Chloro-3-picoline), SCHEMBL73920, SCHEMBL94685, SCHEMBL230963, SCHEMBL792248, SCHEMBL3050556, CHEMBL4648536, SCHEMBL14127194, 2-Chloro-3-methylpyridine, 97%, BCP22229, BBL100505, STL554299, AKOS005145639, AB05179, CS-W011138, GS-6758, AC-23351, SY017766, DB-027924, DB-355580, C1885, NS00026040, EN300-56057, F8880-7769, InChI=1/C6H6ClN/c1-5-3-2-4-8-6(5)7/h2-4H,1H

2-Chloro-3-methylpyridine serves as a key building block in the synthesis of nicotinic acetylcholine receptor agonists for neurological research. It acts as a precursor for crop protection agents, particularly in the development of novel neonicotinoid insecticides. The compound’s reactive sites enable its use in palladium-catalyzed cross-coupling reactions for pharmaceutical intermediates. Researchers also employ it in material science for creating functionalized pyridine derivatives with tailored electronic properties.

Safety and Hazards

GHS Hazard Statements

• H302 (12.8%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (12.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (12.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (12.8%)
• Acute Tox. 4 (12.8%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (12.8%)
• STOT SE 3 (97.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.