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Atomfair 2-Chloro-3-iodopyridine C5H3ClIN CAS 78607-36-0

2-Chloro-3-iodopyridine (CAS No. 78607-36-0) is a high-purity halogenated pyridine derivative with the molecular formula C5H3ClIN . This heteroaromatic compound is a versatile building block in pharmaceutical and agrochemical synthesis, offering dual reactivity at the 2-chloro and 3-iodo positions for selective cross-coupling reactions (e.g., Suzuki, Stille, Negishi). The crystalline solid exhibits >98% purity (HPLC) with controlled moisture content (<0.5% by Karl Fischer). Packaged under inert gas in amber glass bottles to prevent degradation, this air-sensitive reagent is ideal for palladium-catalyzed transformations, nucleophilic substitutions, and metal-halogen exchange reactions. NMR (1H, 13C) and LC-MS spectra are available for quality verification. Store at 2-8°C…

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Description

2-Chloro-3-iodopyridine (CAS No. 78607-36-0) is a high-purity halogenated pyridine derivative with the molecular formula C5H3ClIN. This heteroaromatic compound is a versatile building block in pharmaceutical and agrochemical synthesis, offering dual reactivity at the 2-chloro and 3-iodo positions for selective cross-coupling reactions (e.g., Suzuki, Stille, Negishi). The crystalline solid exhibits >98% purity (HPLC) with controlled moisture content (<0.5% by Karl Fischer). Packaged under inert gas in amber glass bottles to prevent degradation, this air-sensitive reagent is ideal for palladium-catalyzed transformations, nucleophilic substitutions, and metal-halogen exchange reactions. NMR (1H, 13C) and LC-MS spectra are available for quality verification. Store at 2-8°C with desiccant.

Properties

  • CAS Number: 78607-36-0
  • Complexity: 78.8
  • IUPAC Name: 2-chloro-3-iodo-pyridine
  • InChI: InChI=1S/C5H3ClIN/c6-5-4(7)2-1-3-8-5/h1-3H
  • InChI Key: OHWSWGXNZDSHLM-UHFFFAOYSA-N
  • Exact Mass: 238.89987
  • Molecular Formula: C5H3ClIN
  • Molecular Weight: 239.44
  • SMILES: C1=CC(=C(N=C1)Cl)I
  • Topological: 12.9
  • Monoisotopic Mass: 238.89987
  • Synonyms: 2-chloro-3-iodopyridine, 78607-36-0, DTXSID40370916, DTXCID10321950, 675-002-3, Pyridine, 2-chloro-3-iodo-, MFCD00661298, 2-Chloro-3-iodo-pyridine, 3-iodo-2-chloropyridine, SCHEMBL165854, SCHEMBL229863, 2-chloranyl-3-iodanyl-pyridine, Ciprofloxacin Related Compound A, 2-Chloro-3-iodopyridine, 97%, ALBB-028501, BCP03191, CS-D0940, GEO-02627, SBB013979, STK688514, AKOS005137882, AB06631, AC-1103, FC20061, PS-7596, BP-10801, HY-32753, SY004388, DB-027601, ST4128291, C2193, EN300-93247, A809376, AJ-333/25006075

Application

2-Chloro-3-iodopyridine serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) through sequential functionalization of its halogen sites. The compound is particularly valuable in constructing pyridine-based kinase inhibitors and antimicrobial agents via transition metal-catalyzed cross-coupling. Its differential halogen reactivity enables orthogonal modification strategies in medicinal chemistry workflows. Researchers also utilize it as a precursor for radiolabeling (125I) in PET tracer development.

Safety and Hazards

GHS Hazard Statements

  • H302 (93.8%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H312 (10.4%): Harmful in contact with skin [Warning Acute toxicity, dermal]
  • H315 (20.8%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H318 (79.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
  • H319 (20.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H332 (14.6%): Harmful if inhaled [Warning Acute toxicity, inhalation]
  • H335 (18.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (93.8%)
  • Acute Tox. 4 (10.4%)
  • Skin Irrit. 2 (20.8%)
  • Eye Dam. 1 (79.2%)
  • Eye Irrit. 2A (20.8%)
  • Acute Tox. 4 (14.6%)
  • STOT SE 3 (18.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

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  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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