Description

2-Chloro-3-fluoropyridine (CAS No. 17282-04-1) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₃ClFN. This heterocyclic compound is a valuable building block in pharmaceutical, agrochemical, and material science research due to its reactive chloro and fluoro substituents. Its IUPAC name is 2-chloro-3-fluoropyridine, and it is characterized by a clear to pale-yellow appearance, typically supplied as a liquid or low-melting solid. With a molecular weight of 131.54 g/mol, this compound is widely used in cross-coupling reactions, nucleophilic substitutions, and as a precursor for advanced intermediates. Store under inert conditions at recommended temperatures to maintain stability.

Properties

• CAS Number: 17282-04-1
• Complexity: 78.8
• IUPAC Name: 2-chloro-3-fluoro-pyridine
• InChI: InChI=1S/C5H3ClFN/c6-5-4(7)2-1-3-8-5/h1-3H
• InChI Key: SVAZIMBLBHOVIR-UHFFFAOYSA-N
• Exact Mass: 130.9938050
• Molecular Formula: C5H3ClFN
• Molecular Weight: 131.53
• SMILES: C1=CC(=C(N=C1)Cl)F
• Topological: 12.9
• Monoisotopic Mass: 130.9938050
• Synonyms: 2-Chloro-3-fluoropyridine, 17282-04-1, DTXSID60382298, DTXCID80333323, 629-118-6, 3-FLUORO-2-CHLOROPYRIDINE, 2-Chloro-3-Fluoro Pyridine, MFCD03095302, 2-Chloro-3-fluoro-pyridine, Pyridine, 2-chloro-3-fluoro-, fluorochloropyridine, SCHEMBL105057, SCHEMBL230133, SCHEMBL1044994, SCHEMBL17316408, SVAZIMBLBHOVIR-UHFFFAOYSA-N, 2-Chloro-3-fluoropyridine, 97%, BCP22126, RB1059, SBB085791, AKOS005063977, AB13662, AC-2663, CS-W020185, FC55489, PS-9140, DB-023782, DB-025365, C2447, EN300-56059, F0001-0627, Z850328566

Application

2-Chloro-3-fluoropyridine serves as a versatile intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of antiviral and antibacterial agents. It is also employed in agrochemical research for creating novel pesticides and herbicides due to its bioactivity. Additionally, this compound finds use in material science for designing functionalized pyridine-based ligands and polymers.

Safety and Hazards

GHS Hazard Statements

• H302 (89.6%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (16.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (95.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (14.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (89.6%)
• Skin Irrit. 2 (16.7%)
• Eye Dam. 1 (95.8%)
• STOT SE 3 (14.6%)

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