Description

2-Chloro-3-fluoroaniline (CAS No. 21397-08-0) is a high-purity halogenated aniline derivative with the molecular formula C₆H₅ClFN. This aromatic amine features both chloro and fluoro substituents on the benzene ring, offering unique reactivity for advanced organic synthesis. Ideal for pharmaceutical intermediates, agrochemical research, and material science applications, our product is rigorously tested to ensure ≥98% purity (GC) with controlled moisture content. Supplied in amber glass bottles under inert atmosphere to prevent degradation, this compound is a versatile building block for cross-coupling reactions, nucleophilic substitutions, and heterocycle formation. Technical specifications include molecular weight 145.56 g/mol, boiling point 210-212°C, and density 1.35 g/cm³. SDS and COA available upon request.

Properties

• CAS Number: 21397-08-0
• Complexity: 99.1
• IUPAC Name: 2-chloro-3-fluoro-aniline
• InChI: InChI=1S/C6H5ClFN/c7-6-4(8)2-1-3-5(6)9/h1-3H,9H2
• InChI Key: FJKIADFDXOCBRV-UHFFFAOYSA-N
• Exact Mass: 145.0094550
• Molecular Formula: C6H5ClFN
• Molecular Weight: 145.56
• SMILES: C1=CC(=C(C(=C1)F)Cl)N
• Topological: 26
• Monoisotopic Mass: 145.0094550
• Synonyms: 2-Chloro-3-fluoroaniline, 21397-08-0, 2-chloro-3-fluorobenzenamine, EINECS 244-366-1, DTXSID30175659, DTXCID8098150, 244-366-1, 2-chloro-3-fluoro aniline, 2-Chloro-3-fluoro-aniline, Benzenamine, 2-chloro-3-fluoro-, MFCD03407961, C57TJ6HK3A, 2-chloro-3-fluorophenylamine, SCHEMBL108884, 2-chloro-3-fluoro-phenylamine, Aniline, 2-chloro-3-fluoro-, SCHEMBL6825826, SCHEMBL8880192, SCHEMBL8880194, SBB069990, AKOS006346485, AB14054, AC-3665, CS-W009260, FC03088, PS-8952, SY029015, DB-006042, NS00049762, EN300-116062, F0001-2452, Z1201622187

Application

2-Chloro-3-fluoroaniline serves as a key precursor in the synthesis of fluorinated quinoline antibiotics and kinase inhibitor pharmaceuticals. The compound’s orthogonal halogen substitution pattern enables selective functionalization in palladium-catalyzed cross-coupling reactions. Researchers utilize this intermediate in developing novel crop protection agents due to its bioisosteric potential in pesticide formulations. The electron-withdrawing effects of both halogens make it particularly valuable for constructing electron-deficient aromatic systems in OLED materials.

Safety and Hazards

GHS Hazard Statements

• H227 (20%): Combustible liquid [Warning Flammable liquids]
• H302+H312+H332 (20%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H302 (40%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (40%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (40%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403, P403+P233, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 4 (20%)
• Acute Tox. 4 (40%)
• Acute Tox. 4 (40%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (40%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.