Description

2-Chloro-1-ethoxy-3-fluorobenzene (CAS No. 909122-13-0) is a high-purity fluorinated aromatic compound with the molecular formula C₈H₈ClFO. This specialized chemical features a chloro- and fluoro-substituted benzene ring with an ethoxy functional group, making it a valuable intermediate in synthetic organic chemistry. Its precise structure (IUPAC name: 2-chloro-1-ethoxy-3-fluorobenzene) ensures consistent reactivity for nucleophilic substitutions and cross-coupling reactions. Packaged under inert conditions to maintain stability, this compound is ideal for pharmaceutical development, agrochemical research, and material science applications. Available in quantities from grams to kilograms with ≥95% purity (GC/MS verified).

Properties

• CAS Number: 909122-13-0
• Complexity: 121
• IUPAC Name: 2-chloro-1-ethoxy-3-fluoro-benzene
• InChI: InChI=1S/C8H8ClFO/c1-2-11-7-5-3-4-6(10)8(7)9/h3-5H,2H2,1H3
• InChI Key: YUISJPJFLCRVPC-UHFFFAOYSA-N
• Exact Mass: 174.0247707
• Molecular Formula: C8H8ClFO
• Molecular Weight: 174.60
• SMILES: CCOC1=C(C(=CC=C1)F)Cl
• Topological: 9.2
• Monoisotopic Mass: 174.0247707
• Synonyms: 2-chloro-1-ethoxy-3-fluorobenzene, 909122-13-0, SCHEMBL2885551, YUISJPJFLCRVPC-UHFFFAOYSA-N, 1-Ethoxy-2-chloro-3-fluorobenzene, JLB12213, AKOS033756265, CS-0459467, EN300-212105, Z1726058748

Application

2-Chloro-1-ethoxy-3-fluorobenzene serves as a key building block in the synthesis of complex fluorinated aromatic systems. It is widely used in pharmaceutical research for developing bioactive molecules with enhanced metabolic stability. The compound’s unique substitution pattern facilitates Suzuki-Miyaura and Buchwald-Hartwig coupling reactions. Researchers also utilize it in agrochemical formulations to modify pesticide lipophilicity.

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