Description

2-Chloro-1-(chloromethyl)-4-fluorobenzene (CAS No. 93286-22-7) is a high-purity halogenated aromatic compound with the molecular formula C₇H₅Cl₂F. This versatile intermediate is characterized by its dual chloro- and fluorofunctional groups, making it a valuable building block for pharmaceutical synthesis, agrochemical production, and advanced material research. The compound is supplied as a clear to pale yellow liquid with a purity of ≥98% (GC), ensuring consistency for sensitive applications. Proper storage under inert atmosphere at 2-8°C is recommended to maintain stability. Strict handling protocols should be followed due to its lachrymatory properties and moisture sensitivity. Available in research quantities (100mg-1kg) with optional custom packaging.

Properties

• CAS Number: 93286-22-7
• Complexity: 108
• IUPAC Name: 2-chloro-1-(chloromethyl)-4-fluoro-benzene
• InChI: InChI=1S/C7H5Cl2F/c8-4-5-1-2-6(10)3-7(5)9/h1-3H,4H2
• InChI Key: HMIAXVWVTBIGON-UHFFFAOYSA-N
• Exact Mass: 177.9752337
• Molecular Formula: C7H5Cl2F
• Molecular Weight: 179.02
• SMILES: C1=CC(=C(C=C1F)Cl)CCl
• Monoisotopic Mass: 177.9752337
• Synonyms: 2-chloro-1-(chloromethyl)-4-fluorobenzene, 679-271-8, 2-Chloro-4-fluorobenzyl chloride, 93286-22-7, 2-chloro-1-(chloromethyl)-4-fluoro-benzene, BENZENE, 2-CHLORO-1-(CHLOROMETHYL)-4-FLUORO-, MFCD00236026, SCHEMBL531667, DTXSID70369353, HMIAXVWVTBIGON-UHFFFAOYSA-N, SBB005760, STL197884, AKOS000400729, PS-10670, DB-024286, C1998, CS-0179770, ST51029056, EN300-18254

Application

This bifunctional halogenated benzene derivative serves as a key precursor in Suzuki coupling reactions for creating complex fluorinated biphenyl systems. Researchers utilize it in developing novel antimicrobial agents by exploiting the reactivity of both chlorine substituents. The compound’s unique substitution pattern enables selective transformations in pharmaceutical intermediate synthesis, particularly for CNS-active compounds. It also finds application in liquid crystal material development where fluorinated aromatic cores are required.

Safety and Hazards

GHS Hazard Statements

• H290 (16.7%): May be corrosive to metals [Warning Corrosive to Metals]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (16.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Precautionary Statements

• P234, P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P390, P405, P406, and P501

Hazard Classes and Categories

• Met. Corr. 1 (16.7%)
• Skin Corr. 1B (100%)
• Eye Dam. 1 (16.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.