Atomfair (2-Bromopyridin-4-yl)methanol C6H6BrNO CAS 118289-16-0

Description

(2-Bromopyridin-4-yl)methanol (CAS No. 118289-16-0) is a high-purity brominated pyridine derivative with the molecular formula C₆H₆BrNO. This versatile intermediate is widely used in pharmaceutical synthesis, agrochemical development, and advanced material research. The compound features a hydroxymethyl group at the 4-position and a bromine substituent at the 2-position of the pyridine ring, making it an excellent building block for cross-coupling reactions and other functional group transformations.

Our product is manufactured under strict quality control standards to ensure >96% purity (HPLC) with low levels of impurities. Available in gram to kilogram quantities with Certificate of Analysis, it is suitable for medicinal chemistry, heterocyclic compound synthesis, and ligand preparation. The compound is provided as a white to off-white crystalline powder with stable shelf life when stored at 2-8°C under inert atmosphere.

Key applications include: Suzuki-Miyaura coupling reactions, nucleophilic substitutions, and as precursor for pyridine-based catalysts. The product is packaged in amber glass bottles with PTFE-lined caps to ensure stability and shipped with all required safety documentation (SDS available upon request).

Properties

• CAS Number: 118289-16-0
• Complexity: 89.1
• IUPAC Name: (2-bromo-4-pyridyl)methanol
• InChI: InChI=1S/C6H6BrNO/c7-6-3-5(4-9)1-2-8-6/h1-3,9H,4H2
• InChI Key: IQNUGAFIKDRYRP-UHFFFAOYSA-N
• Exact Mass: 186.96328
• Molecular Formula: C6H6BrNO
• Molecular Weight: 188.02
• SMILES: C1=CN=C(C=C1CO)Br
• Topological: 33.1
• Monoisotopic Mass: 186.96328
• Synonyms: 118289-16-0, (2-bromopyridin-4-yl)methanol, DTXSID50561156, DTXCID50511934, 663-333-6, 2-Bromopyridine-4-methanol, 2-bromo-4-hydroxymethylpyridine, 2-bromo-4-pyridinemethanol, 2-BROMO-4-(HYDROXYMETHYL)PYRIDINE, MFCD04039313, (2-bromo-4-pyridyl)methan-1-ol, 4-PYRIDINEMETHANOL, 2-BROMO-, 2-bromopyridin-4-methanol, SCHEMBL1166951, SCHEMBL6476900, (2-bromopyridin-4-yl)-methanol, 2-Bromo-4-hydroxymethyl-pyridine, 4-hydroxymethyl-2-pyridyl bromide, IQNUGAFIKDRYRP-UHFFFAOYSA-N, (2-bromo-pyridin-4-yl)-methanol, SBB054782, AKOS005257219, 2-Bromo-4-hydroxymethylpyridine, 96%, AC-5438, CS-W000831, SY017970, TS-02642, DB-006037, ST50827669, EN300-75760

(2-Bromopyridin-4-yl)methanol serves as a key intermediate in the synthesis of pharmaceutical compounds, particularly in developing kinase inhibitors and antimicrobial agents. The compound is valuable in palladium-catalyzed cross-coupling reactions for constructing complex heterocyclic systems. Researchers utilize this building block in medicinal chemistry programs to introduce functionalized pyridine moieties into target molecules. Its dual functionality (bromo and hydroxymethyl groups) enables diverse derivatization pathways for drug discovery applications.

Safety and Hazards

GHS Hazard Statements

• H302 (90.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (90.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (90.7%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (90.7%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.