Description

2-(Bromomethyl)-1,3-difluorobenzene (CAS No. 85118-00-9) is a highly specialized aromatic compound with the molecular formula C₇H₅BrF₂. This organobromine derivative features a bromomethyl group adjacent to two fluorine atoms on a benzene ring, making it a versatile intermediate in synthetic organic chemistry. With a purity of ≥97%, this reagent is ideal for nucleophilic substitution reactions, cross-coupling protocols, and the synthesis of fluorinated pharmaceuticals or agrochemicals. It is supplied as a clear to pale-yellow liquid, stored under inert conditions to ensure stability. Suitable for use in research laboratories and industrial-scale applications, this compound is handled with strict adherence to safety protocols due to its lachrymatory and potential skin-irritating properties.

Properties

• CAS Number: 85118-00-9
• Complexity: 97.8
• IUPAC Name: 2-(bromomethyl)-1,3-difluoro-benzene
• InChI: InChI=1S/C7H5BrF2/c8-4-5-6(9)2-1-3-7(5)10/h1-3H,4H2
• InChI Key: LSXJPJGBWSZHTM-UHFFFAOYSA-N
• Exact Mass: 205.95427
• Molecular Formula: C7H5BrF2
• Molecular Weight: 207.01
• SMILES: C1=CC(=C(C(=C1)F)CBr)F
• Monoisotopic Mass: 205.95427
• Synonyms: 2,6-Difluorobenzyl bromide, 85118-00-9, 2-(Bromomethyl)-1,3-difluorobenzene, Benzene, 2-(bromomethyl)-1,3-difluoro-, FNK4D2QCW3, EINECS 285-652-6, LSXJPJGBWSZHTM-UHFFFAOYSA-, DTXSID10234238, DTXCID10156729, 285-652-6, inchi=1/c7h5brf2/c8-4-5-6(9)2-1-3-7(5)10/h1-3h,4h2, 2,6-Difluorobenzylbromide, alpha-Bromo-2,6-difluorotoluene, MFCD00000329, UNII-FNK4D2QCW3, 2,6-diflourobenzyl bromide, 2,6-Difluoro-benzyl bromide, SCHEMBL121801, 2,6-difluoro-a-bromo-toluene, 2,6-difluoro-alpha-bromotoluene, SCHEMBL23495267, 2,6-difluoro-alpha-bromo-toluene, alpha-bromo-2,6-di-fluorotoluene, 2,6-Difluorobenzyl bromide, 97%, 2-Bromomethyl-1,3-difluorobenzene, .alpha.-Bromo-2,6-difluorotoluene, 2-bromomethyl-1,3-difluoro-benzene, SBB006564, AKOS005259827, AC-9735, CS-W015290, 2-(Bromomethyl)-1,3-difluorobenzene #, AS-12849, DB-013578, DB-024263, D2576, NS00065099, ST51039977, EN300-157269, Q27452737

2-(Bromomethyl)-1,3-difluorobenzene is widely employed as a key building block in the synthesis of fluorinated aromatic compounds, particularly in pharmaceutical and materials science research. It serves as a precursor for ligands, catalysts, and biologically active molecules due to its reactive bromomethyl group. Applications include Suzuki-Miyaura couplings and Grignard reactions to introduce difluorobenzyl motifs. It is also utilized in the development of liquid crystals and advanced polymers requiring fluorine-substituted aromatic cores.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.