Description

2-Bromoisonicotinic acid (CAS No. 66572-56-3) is a high-purity brominated pyridine carboxylic acid derivative with the molecular formula C₆H₄BrNO₂. This compound, also known by its IUPAC name 2-bromopyridine-4-carboxylic acid, is a versatile heterocyclic building block widely used in pharmaceutical synthesis, agrochemical research, and material science applications. The presence of both bromine and carboxylic acid functional groups on the pyridine ring makes it a valuable intermediate for nucleophilic substitution reactions, metal-catalyzed cross-couplings, and derivatization reactions.

Our product is supplied as a crystalline solid with ≥95% purity (HPLC) and undergoes rigorous quality control to ensure batch-to-batch consistency. Suitable for use in medicinal chemistry, it serves as a precursor for the development of kinase inhibitors, receptor modulators, and other bioactive molecules. Researchers will appreciate the compound’s stability under inert atmosphere and compatibility with common organic solvents including DMF, DMSO, and methanol.

Each shipment includes comprehensive analytical data (NMR, HPLC, MS) and is packaged in amber glass vials with optional argon purging for oxygen-sensitive applications. Available quantities range from 100mg to 100g scale with custom synthesis options.

Properties

• CAS Number: 66572-56-3
• Complexity: 140
• IUPAC Name: 2-bromopyridine-4-carboxylic acid
• InChI: InChI=1S/C6H4BrNO2/c7-5-3-4(6(9)10)1-2-8-5/h1-3H,(H,9,10)
• InChI Key: YBTKGKVQEXAYEM-UHFFFAOYSA-N
• Exact Mass: 200.94254
• Molecular Formula: C6H4BrNO2
• Molecular Weight: 202.01
• SMILES: C1=CN=C(C=C1C(=O)O)Br
• Topological: 50.2
• Monoisotopic Mass: 200.94254
• Synonyms: 2-bromoisonicotinic acid, DTXSID90278711, DTXCID70229867, 626-472-3, 66572-56-3, 2-Bromopyridine-4-carboxylic acid, 2-Bromo-4-Pyridinecarboxylic Acid, 2-Bromo-isonicotinic acid, 2-Bromo-4-pyridine carboxylic acid, MFCD01646069, F1926-0035, 4-pyridinecarboxylic acid, 2-bromo-, NSC9462, 2-bromoisonicotinicacid, 2-bromo isonicotinic acid, SCHEMBL40395, 2-bromo-4pyridinecarboxylic acid, 2-bromo4-pyridine carboxylic acid, SMSSF-0044426, 2-bromo-pyridine-4-carboxylic acid, BCP22077, NSC-9462, STR07889, SBB028531, AKOS002664348, AB09563, AC-1147, CS-W002805, FB36844, HY-W002805, PS-4081, 2-Bromopyridine-4-carboxylic acid, 97%, SY017174, DB-009073, DB-217106, B3368, ST50827439, EN300-87414, AC-907/30003053, Z1259086653, 2-Bromoisonicotinic acid;2-Bromo-4-Pyridinecarboxylic Acid

Application

2-Bromoisonicotinic acid serves as a key synthetic intermediate in the preparation of pharmaceutical compounds, particularly in the development of nicotinic acid derivatives with potential therapeutic applications. The bromine substituent enables efficient palladium-catalyzed cross-coupling reactions for constructing complex heterocyclic systems. Researchers utilize this compound as a building block for metal-organic frameworks (MOFs) due to its bifunctional reactivity. In agrochemical research, it finds use in the synthesis of novel pyridine-based pesticides and herbicides.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.