Description

2-Bromo-6-methylpyridine (CAS No. 5315-25-3) is a high-purity halogenated pyridine derivative with the molecular formula C₆H₆BrN. This compound is a versatile building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its bromine and methyl substituents at the 2- and 6-positions of the pyridine ring enable selective functionalization via cross-coupling reactions (e.g., Suzuki, Stille) or nucleophilic substitutions. Available in >98% purity (GC), this crystalline solid is packaged under inert gas to ensure stability. Ideal for developing active pharmaceutical ingredients (APIs), ligands, and specialty chemicals. Store in a cool, dry place away from light. MSDS and analytical certificates available upon request.

Properties

• CAS Number: 5315-25-3
• Complexity: 74.9
• IUPAC Name: 2-bromo-6-methyl-pyridine
• InChI: InChI=1S/C6H6BrN/c1-5-3-2-4-6(7)8-5/h2-4H,1H3
• InChI Key: SOHDPICLICFSOP-UHFFFAOYSA-N
• Exact Mass: 170.96836
• Molecular Formula: C6H6BrN
• Molecular Weight: 172.02
• SMILES: CC1=NC(=CC=C1)Br
• Topological: 12.9
• Monoisotopic Mass: 170.96836
• Synonyms: 2-Bromo-6-methylpyridine, 5315-25-3, Pyridine, 2-bromo-6-methyl-, EINECS 226-173-4, AI3-62420, DTXSID70201229, DTXCID20123720, 226-173-4, 2-Bromo-6-picoline, 6-Bromo-2-picoline, 6-bromo-2-methylpyridine, 2-Bromo-6-Methyl Pyridine, 2-bromo-6-methyl-pyridine, MFCD00040743, 6-bromopicoline, 2-Bromo-6-methylpyridine; 2-Bromo-6-picoline; 2-Methyl-6-bromopyridine; 6-Bromo-2-methylpyridine; 6-Methyl-2-bromopyridine;, 6-methyl-2-bromopyridine, SCHEMBL103431, SCHEMBL1310758, SCHEMBL1515232, SCHEMBL1758569, SCHEMBL3834849, SCHEMBL8029519, 2-Bromo-6-methylpyridine, 98%, BCP21092, SBB054376, AKOS005255682, AB01812, AC-2547, CS-W002190, FB30538, PS-5747, SY001968, DB-006025, B2114, NS00032665, ST50827346, EN300-75230, doi:10.14272/SOHDPICLICFSOP-UHFFFAOYSA-N.1, F0001-1369, Z600403652

Application

2-Bromo-6-methylpyridine serves as a key intermediate in synthesizing pharmaceuticals, including kinase inhibitors and CNS-active compounds. Its bromine moiety facilitates palladium-catalyzed couplings to construct biaryl systems. Researchers also employ it to prepare pyridine-based ligands for catalysis. In agrochemistry, it aids in developing pyridinyl herbicides and fungicides.

Safety and Hazards

GHS Hazard Statements

• H302 (11.8%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (90.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (11.8%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (90.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.