Description

2-Bromo-6-chloro-4-fluoroaniline (CAS No. 201849-14-1) is a high-purity halogenated aniline derivative with the molecular formula C₆H₄BrClFN. This compound is a valuable building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring bromo, chloro, and fluoro substituents on the aniline ring, enables selective functionalization for the development of complex molecules. Ideal for cross-coupling reactions, nucleophilic substitutions, and as a precursor for heterocyclic compounds. Supplied as a crystalline solid with ≥95% purity (HPLC), rigorously tested for consistency and stability. Store under inert conditions at 2-8°C to maintain integrity.

Properties

• CAS Number: 201849-14-1
• Complexity: 124
• IUPAC Name: 2-bromo-6-chloro-4-fluoro-aniline
• InChI: InChI=1S/C6H4BrClFN/c7-4-1-3(9)2-5(8)6(4)10/h1-2H,10H2
• InChI Key: LIBGMUMMWYKJSC-UHFFFAOYSA-N
• Exact Mass: 222.91997
• Molecular Formula: C6H4BrClFN
• Molecular Weight: 224.46
• SMILES: C1=C(C=C(C(=C1Cl)N)Br)F
• Topological: 26
• Monoisotopic Mass: 222.91997
• Synonyms: 2-Bromo-6-chloro-4-fluoroaniline, 201849-14-1, DTXSID30346726, DTXCID20297798, 606-453-6, Benzenamine, 2-bromo-6-chloro-4-fluoro-, MFCD00051707, SCHEMBL2720754, SBB096694, 2-bromo-6-chloro-4-fluorophenylamine, 6-bromo-2-chloro-4-fluorophenylamine, AKOS005258192, AC-1574, CS-W010443, 2-Bromo-6-chloro-4-fluoroaniline, 97%, DS-12650, DB-045123, B3681, NS00123147, ST50320234, EN300-121004

Application

2-Bromo-6-chloro-4-fluoroaniline is widely used as a key intermediate in the synthesis of pharmaceuticals, such as kinase inhibitors and antimicrobial agents. Its halogen-rich structure facilitates palladium-catalyzed coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for drug discovery. In agrochemical research, it serves as a precursor for herbicides and pesticides due to its reactivity. Also employed in material science for designing functionalized aromatic polymers.

Safety and Hazards

GHS Hazard Statements

• H302 (10.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (10.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (10.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (10.9%)
• Acute Tox. 4 (10.9%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (10.9%)
• STOT SE 3 (97.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.