Description

2-Bromo-5-(trifluoromethyl)pyridine (CAS No. 50488-42-1) is a high-purity halogenated pyridine derivative with the molecular formula C₆H₃BrF₃N. This compound features a bromine substituent at the 2-position and a trifluoromethyl group at the 5-position of the pyridine ring, making it a versatile building block for pharmaceutical, agrochemical, and materials science applications. Its unique electronic properties and reactivity profile enable its use in cross-coupling reactions, nucleophilic substitutions, and as a precursor for synthesizing complex heterocycles. Available in ≥97% purity, this product is rigorously tested for consistency and quality, ensuring optimal performance in research and industrial settings. Packaged under inert conditions to maintain stability, it is ideal for use in organometallic catalysis, medicinal chemistry, and advanced material design.

Properties

• CAS Number: 50488-42-1
• Complexity: 136
• IUPAC Name: 2-bromo-5-(trifluoromethyl)pyridine
• InChI: InChI=1S/C6H3BrF3N/c7-5-2-1-4(3-11-5)6(8,9)10/h1-3H
• InChI Key: GSKMWMFOQQBVMI-UHFFFAOYSA-N
• Exact Mass: 224.94010
• Molecular Formula: C6H3BrF3N
• Molecular Weight: 225.99
• SMILES: C1=CC(=NC=C1C(F)(F)F)Br
• Topological: 12.9
• Monoisotopic Mass: 224.94010
• Synonyms: 2-Bromo-5-(trifluoromethyl)pyridine, 50488-42-1, DTXSID20371360, DTXCID40322394, 628-661-6, 2-bromo-5-trifluoromethylpyridine, MFCD00153086, 2-bromo-5-trifluoromethyl-pyridine, 5-(trifluoromethyl)-2-bromopyridine, 6-Bromo-3-trifluoromethylpyridine, PYRIDINE, 2-BROMO-5-(TRIFLUOROMETHYL)-, 2-Bromo-5-Trifluoromethyl Pyridine, SCHEMBL67213, 5-trifluoromethyl-2-bromopyridine, QWISXWNESLHVBD-UHFFFAOYSA-N, RB1670, SBB054390, 2-bromo-5-(trifluoromethyl)-pyridine, 2-Bromo-5-(trifluoromethyl) pyridine, AKOS005063713, AB04065, AC-9487, CS-W008678, FG-0478, 2-Bromo-5-(trifluoromethyl)pyridine, 97%, DB-010103, ST50826923, EN300-68433, 6-Bromo-alpha,alpha,alpha-trifluoro-3-picoline, Z415645014

2-Bromo-5-(trifluoromethyl)pyridine serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals, particularly in Suzuki-Miyaura and Buchwald-Hartwig couplings. Its trifluoromethyl group enhances lipophilicity and metabolic stability in drug candidates, while the bromine moiety facilitates further functionalization. Researchers also employ it in the development of liquid crystals, OLED materials, and ligands for catalysis. Suitable for both small-scale laboratory use and bulk industrial applications.

Safety and Hazards

GHS Hazard Statements

• H300 (83%): Fatal if swallowed [Danger Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 2 (83%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.