Description

2-Bromo-5-(trifluoromethyl)benzenamine (CAS No. 454-79-5) is a high-purity aromatic amine derivative with the molecular formula C₇H₅BrF₃N. This compound features a bromo-substituted benzene ring with a trifluoromethyl group and an amine functional group at the 2- and 5-positions, respectively, making it a versatile intermediate in organic synthesis and pharmaceutical research. It is widely utilized in the preparation of agrochemicals, pharmaceuticals, and specialty chemicals due to its unique reactivity profile. Available in various packaging options, our product undergoes rigorous quality control to ensure ≥97% purity (GC), meeting the stringent demands of industrial and academic laboratories. Store in a cool, dry place under inert conditions to maintain stability.

Properties

• CAS Number: 454-79-5
• Complexity: 159
• IUPAC Name: 2-bromo-5-(trifluoromethyl)aniline
• InChI: InChI=1S/C7H5BrF3N/c8-5-2-1-4(3-6(5)12)7(9,10)11/h1-3H,12H2
• InChI Key: PZDVFXUBTKPFSG-UHFFFAOYSA-N
• Exact Mass: 238.95575
• Molecular Formula: C7H5BrF3N
• Molecular Weight: 240.02
• SMILES: C1=CC(=C(C=C1C(F)(F)F)N)Br
• Topological: 26
• Monoisotopic Mass: 238.95575
• Synonyms: 454-79-5, 2-Bromo-5-trifluoromethylaniline, 2-bromo-5-(trifluoromethyl)benzenamine, 2-Bromo-5-trifluoromethylphenylamine, Benzenamine, 2-bromo-5-(trifluoromethyl)-, 6-Bromo-alpha,alpha,alpha-trifluoro-m-toluidine, SD827XN4S2, EINECS 207-227-6, NSC-88276, 2-Amino-4-trifluoromethyl-1-bromobenzene, DTXSID40196496, NSC 88276, 5-TRIFLUOROMETHYL-2-BROMOANILINE, DTXCID50118987, 207-227-6, 2-Bromo-5-(trifluoromethyl)aniline, 3-Amino-4-bromobenzotrifluoride, 4-Bromo-3-aminobenzotrifluoride, MFCD00007637, 6-Bromo-.alpha.,.alpha.,.alpha.-trifluoro-m-toluidine, 2-bromo-5-(trifluoromethyl)phenylamine, 2-Amino-1-bromo-4-trifluoromethylbenzene, NSC88276, NCIOpen2_005146, UNII-SD827XN4S2, SCHEMBL780388, SBB099190, 2-bromanyl-5-(trifluoromethyl)aniline, 2-Bromo-5-(trifluoromethyl)aniline #, AKOS000147997, AC-2798, CS-W001184, PS-7593, 2-bromo-5-(trifluoromethyl)benzeneamine, [2-bromo-5-(trifluoromethyl)phenyl]amine, 2-Bromo-5-(trifluoromethyl)aniline, 97%, DB-027857, A1483, NS00043469, ST50307063, EN300-86068, A826819

2-Bromo-5-(trifluoromethyl)benzenamine serves as a key building block in the synthesis of fluorinated heterocycles and active pharmaceutical ingredients (APIs). Its electron-withdrawing trifluoromethyl group enhances reactivity in cross-coupling reactions, such as Suzuki or Buchwald-Hartwig couplings. Researchers employ this compound in the development of herbicides, fungicides, and bioactive molecules targeting neurological disorders. It is also used in material science for designing advanced polymers with tailored properties.

Safety and Hazards

GHS Hazard Statements

• H302 (16.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H314 (85.4%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (16.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (83.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (16.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (16.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

• P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P321, P330, P332+P317, P337+P317, P362+P364, P363, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (16.7%)
• Skin Corr. 1B (85.4%)
• Skin Irrit. 2 (16.7%)
• Eye Dam. 1 (83.3%)
• Eye Irrit. 2A (16.7%)
• Acute Tox. 4 (16.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.