Description

2-Bromo-5-(trifluoromethoxy)aniline (CAS No. 887267-47-2) is a high-purity aromatic amine derivative featuring a bromo and trifluoromethoxy substitution pattern. With the molecular formula C₇H₅BrF₃NO, this compound is a versatile intermediate in pharmaceutical and agrochemical synthesis. Its unique trifluoromethoxy group enhances lipophilicity and metabolic stability, making it valuable for medicinal chemistry applications. The product is rigorously tested for purity and consistency, ensuring optimal performance in research and industrial processes. Available in various packaging options to meet laboratory-scale and bulk production needs.

Properties

• CAS Number: 887267-47-2
• Complexity: 176
• IUPAC Name: 2-bromo-5-(trifluoromethoxy)aniline
• InChI: InChI=1S/C7H5BrF3NO/c8-5-2-1-4(3-6(5)12)13-7(9,10)11/h1-3H,12H2
• InChI Key: MMRYEBVMIOYMIF-UHFFFAOYSA-N
• Exact Mass: 254.95066
• Molecular Formula: C7H5BrF3NO
• Molecular Weight: 256.02
• SMILES: C1=CC(=C(C=C1OC(F)(F)F)N)Br
• Topological: 35.3
• Monoisotopic Mass: 254.95066
• Synonyms: 2-Bromo-5-(trifluoromethoxy)aniline, 887267-47-2, DTXSID60650404, DTXCID20601154, 678-234-3, 2-Bromo-5-trifluoromethoxyaniline, 2-Bromo-5-(trifluoromethoxy), 2-Amino-1-bromo-4-(trifluoromethoxy)benzene, MFCD08458013, 4-Bromo-3-aminotrifluoromethoxybenzene, SCHEMBL1034163, 2-bromo-5-trifluoromethoxy-aniline, CL8390, SBB101659, AKOS015854684, CS-W012569, PS-7404, 2-bromo-5-(trifluoromethoxy)phenylamine, SY020776, DB-024319, B3107, EN300-175657

2-Bromo-5-(trifluoromethoxy)aniline is widely used as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals. Its trifluoromethoxy group is particularly useful in designing compounds with improved bioavailability and target specificity. Researchers leverage this compound in cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, to construct complex heterocyclic scaffolds. It is also employed in the development of fluorinated analogs for drug discovery programs.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P321, P330, P332+P317, P337+P317, P362+P364, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.