Description

2-Bromo-5-tert-butylpyridine (CAS No. 1142197-19-0) is a high-purity brominated pyridine derivative with the molecular formula C₉H₁₂BrN. This compound features a tert-butyl group at the 5-position and a bromine substituent at the 2-position of the pyridine ring, making it a valuable intermediate in organic synthesis and pharmaceutical research. Its robust structure ensures stability under various reaction conditions, ideal for cross-coupling reactions, ligand synthesis, and functional group transformations. Suitable for researchers and industrial chemists, this product is rigorously tested for quality, with ≥95% purity (GC), and is supplied in secure, light-resistant packaging to maintain integrity. Available in quantities from milligrams to kilograms to meet both lab-scale and bulk requirements.

Properties

• CAS Number: 1142197-19-0
• Complexity: 128
• IUPAC Name: 2-bromo-5-tert-butyl-pyridine
• InChI: InChI=1S/C9H12BrN/c1-9(2,3)7-4-5-8(10)11-6-7/h4-6H,1-3H3
• InChI Key: IOGKQDRGOUALAS-UHFFFAOYSA-N
• Exact Mass: 213.01531
• Molecular Formula: C9H12BrN
• Molecular Weight: 214.10
• SMILES: CC(C)(C)C1=CN=C(C=C1)Br
• Topological: 12.9
• Monoisotopic Mass: 213.01531
• Synonyms: 1142197-19-0, 2-bromo-5-tert-butylpyridine, 870-998-8, 2-BROMO-5-(TERT-BUTYL)PYRIDINE, 2-Bromo-5-tert-butyl-pyridine, Pyridine, 2-bromo-5-(1,1-dimethylethyl)-, MFCD11869554, 2-Bromo-5-t-butylpyridine, SCHEMBL13010773, IOGKQDRGOUALAS-UHFFFAOYSA-N, SVB19719, AKOS015940132, MB10299, AS-79088, SY028938, DB-313724, CS-0133660, EN300-104659, P18025

Application

2-Bromo-5-tert-butylpyridine is widely used as a key building block in pharmaceutical and agrochemical synthesis. It serves as a precursor for Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions to construct complex heterocyclic frameworks. The tert-butyl group enhances steric and electronic properties, making it valuable in ligand design for catalysis. Researchers also employ it in material science for developing functionalized pyridine-based polymers.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.