Description

2-Bromo-5-fluorotoluene (CAS: 452-63-1) is a high-purity halogenated aromatic compound with the molecular formula C₇H₆BrF. This specialized chemical is widely used in pharmaceutical synthesis, agrochemical development, and advanced material research due to its versatile reactivity as a building block for complex organic frameworks. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in sealed containers under inert gas to maintain stability. Ideal for Suzuki coupling, nucleophilic substitution, and other cross-coupling reactions, this compound features both bromo and fluoro functional groups that enable precise regioselective modifications. Available in research (5g, 25g) and bulk quantities (100g+) with optional custom packaging and purity specifications.

• CAS: 452-63-1 | MF: C₇H₆BrF | MW: 189.03 g/mol
• Appearance: Clear colorless to pale yellow liquid
• Density: ~1.5 g/cm³ | Boiling Point: ~200°C
• Storage: 2-8°C under argon | Shelf Life: 24 months
• Hazard Codes: Xi (Irritant) | GHS Pictograms: Exclamation Mark

Properties

• CAS Number: 452-63-1
• Complexity: 94.9
• IUPAC Name: 1-bromo-4-fluoro-2-methyl-benzene
• InChI: InChI=1S/C7H6BrF/c1-5-4-6(9)2-3-7(5)8/h2-4H,1H3
• InChI Key: RJPNVPITBYXBNB-UHFFFAOYSA-N
• Exact Mass: 187.96369
• Molecular Formula: C7H6BrF
• Molecular Weight: 189.02
• SMILES: CC1=C(C=CC(=C1)F)Br
• Monoisotopic Mass: 187.96369
• Synonyms: 2-Bromo-5-fluorotoluene, 452-63-1, 1-Bromo-4-fluoro-2-methylbenzene, Benzene, 1-bromo-4-fluoro-2-methyl-, Z2EZM84G5X, 2-methyl-4-fluorobromobenzene, EINECS 207-203-5, NSC-88287, DTXSID90196421, NSC 88287, 4-FLUORO-2-METHYL-1-BROMOBENZENE, DTXCID00118912, 207-203-5, 3-Fluoro-6-bromotoluene, 5-FLUORO-2-BROMOTOLUENE, 2-bromo-5-fluoro toluene, 1-bromo-4-fluoro-2-methyl-benzene, NSC88287, MFCD00017921, 2-bromo-5fluorotoluene, 2-Bromo-5-fluortoluene, 2-bromo-5-fluoro-toluene, UNII-Z2EZM84G5X, SCHEMBL306113, SCHEMBL3293266, 2-Bromo-5-fluorotoluene, 98%, BCP24566, SBB090884, 1-Bromo-4-fluoro-2-methylbenzene #, AKOS000121866, AC-7083, CS-W007813, AS-11622, DB-024055, B1303, NS00042955, ST50405135, EN300-28931, C91700, InChI=1/C7H6BrF/c1-5-4-6(9)2-3-7(5)8/h2-4H,1H

2-Bromo-5-fluorotoluene serves as a key intermediate in the synthesis of fluorinated liquid crystals and OLED materials. Its dual functional groups make it valuable for constructing biologically active molecules in drug discovery, particularly kinase inhibitors. The compound is also employed in palladium-catalyzed cross-coupling reactions to introduce fluorinated aromatic moieties into agrochemicals.

Safety and Hazards

GHS Hazard Statements

• H226 (91.7%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (91.7%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (95.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.