Description

2-Bromo-5-fluorophenol (CAS No. 147460-41-1) is a high-purity halogenated phenol derivative with the molecular formula C₆H₄BrFO. This compound is a valuable intermediate in organic synthesis, particularly in pharmaceutical and agrochemical research. Its unique structure, featuring both bromine and fluorine substituents on the aromatic ring, makes it an essential building block for the development of novel bioactive molecules. Our product is rigorously tested to ensure ≥98% purity (HPLC/GC) and is supplied in sealed, light-resistant containers to maintain stability. Ideal for Suzuki couplings, nucleophilic substitutions, and other cross-coupling reactions, this reagent is a must-have for researchers working on fluorinated scaffolds or halogenated aromatics.

Key Specifications:

• CAS: 147460-41-1
• Molecular Weight: 191.00 g/mol
• Appearance: White to off-white crystalline solid
• Melting Point: 45-48°C
• Storage: 2-8°C under inert atmosphere
• Hazard Codes: Xi (Irritant)

Properties

• CAS Number: 147460-41-1
• Complexity: 99.1
• IUPAC Name: 2-bromo-5-fluoro-phenol
• InChI: InChI=1S/C6H4BrFO/c7-5-2-1-4(8)3-6(5)9/h1-3,9H
• InChI Key: HUVAOAVBKOVPBZ-UHFFFAOYSA-N
• Exact Mass: 189.94296
• Molecular Formula: C6H4BrFO
• Molecular Weight: 191.00
• SMILES: C1=CC(=C(C=C1F)O)Br
• Topological: 20.2
• Monoisotopic Mass: 189.94296
• Synonyms: 2-Bromo-5-fluorophenol, 147460-41-1, DTXSID50369179, DTXCID00320215, 604-585-9, huvaoavbkovpbz-uhfffaoysa-n, MFCD00040939, 147460-94-4, Phenol, 2-bromo-5-fluoro-, 2-Propenoic acid, 3-[(3-phenyl-2-propenyl)oxy]-, methyl ester, (E,E)-, 2-bromo-5-fluorphenol, 2-bromo-5-fluoro-phenol, SCHEMBL91238, SCHEMBL5961688, 2-Bromo-5-fluorophenol, 97%, SCHEMBL27688247, SBB091224, AKOS005257831, CS-W004135, PS-8369, AC-25966, DB-023744, B2040, NS00122088, ST50827102, EN300-112643, F14857, Z1203161754

Application

2-Bromo-5-fluorophenol serves as a versatile precursor in medicinal chemistry for synthesizing fluorinated drug candidates, particularly kinase inhibitors and CNS-active compounds. Its bromine moiety enables palladium-catalyzed cross-coupling reactions, while the fluorine atom enhances metabolic stability in bioactive molecules. Researchers utilize this compound to develop PET radiotracers due to the ¹⁸F-labeling potential. In material science, it acts as a monomer for specialty polymers with enhanced thermal resistance.

Safety and Hazards

GHS Hazard Statements

• H302 (14.3%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (14.3%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.