Description

2-Bromo-5-chloropyrazine (CAS No. 912773-21-8) is a high-purity halogenated pyrazine derivative with the molecular formula C₄H₂BrClN₂. This heterocyclic compound is a valuable building block in pharmaceutical, agrochemical, and materials science research due to its reactive bromo and chloro substituents, which enable versatile functionalization. The product is rigorously tested for quality, with ≥95% purity confirmed by HPLC and NMR spectroscopy. Supplied as a crystalline solid with excellent stability under recommended storage conditions (2-8°C, inert atmosphere), it is ideal for cross-coupling reactions, nucleophilic substitutions, and as a precursor for complex heterocyclic systems. Each batch is accompanied by comprehensive analytical data (COA) and MSDS for research compliance.

Properties

• CAS Number: 912773-21-8
• Complexity: 80.4
• IUPAC Name: 2-bromo-5-chloro-pyrazine
• InChI: InChI=1S/C4H2BrClN2/c5-3-1-8-4(6)2-7-3/h1-2H
• InChI Key: UXCPLGLOAZWCKO-UHFFFAOYSA-N
• Exact Mass: 191.90899
• Molecular Formula: C4H2BrClN2
• Molecular Weight: 193.43
• SMILES: C1=C(N=CC(=N1)Br)Cl
• Topological: 25.8
• Monoisotopic Mass: 191.90899
• Synonyms: 2-bromo-5-chloropyrazine, 912773-21-8, DTXSID50653323, DTXCID10604073, 696-073-7, 5-Bromo-2-chloropyrazine, MFCD08460074, 2-Bromo-5-chloro-pyrazine, Pyrazine,2-bromo-5-chloro-, SCHEMBL1585841, 2-bromanyl-5-chloranyl-pyrazine, SCHEMBL28775238, UXCPLGLOAZWCKO-UHFFFAOYSA-N, BCP26285, SBB091627, AKOS005259415, BCP9000096, CS-W005165, PB26374, PS-5610, SY056878, DB-010194, EN300-208562, P10599, A843786, Z1198179757

Application

2-Bromo-5-chloropyrazine serves as a key intermediate in Suzuki-Miyaura and Buchwald-Hartwig coupling reactions for drug discovery. It is widely used in the synthesis of biologically active pyrazine derivatives, including kinase inhibitors and antimicrobial agents. The compound’s dual halogen functionality allows selective sequential modifications in medicinal chemistry workflows.

Safety and Hazards

GHS Hazard Statements

• H302 (75%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (25%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (75%)
• Acute Tox. 4 (50%)
• Skin Irrit. 2 (50%)
• Eye Irrit. 2 (50%)
• Acute Tox. 4 (50%)
• STOT SE 3 (25%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.