Description

2-Bromo-5-chlorophenol (CAS No. 13659-23-9) is a high-purity halogenated phenol derivative with the molecular formula C₆H₄BrClO. This compound is widely utilized in organic synthesis, pharmaceutical research, and agrochemical development due to its reactive bromo and chloro functional groups. Its IUPAC name, 2-bromo-5-chlorophenol, reflects its precise substitution pattern, making it a valuable intermediate for regioselective reactions. Available in crystalline or powder form, our product undergoes rigorous QC testing (including HPLC, GC-MS, and NMR) to ensure ≥98% purity, ideal for demanding laboratory applications. Suitable for use as a building block in Suzuki couplings, etherifications, and other cross-coupling methodologies. Store in a cool, dry place under inert conditions to maintain stability.

Properties

• CAS Number: 13659-23-9
• Complexity: 99.1
• IUPAC Name: 2-bromo-5-chloro-phenol
• InChI: InChI=1S/C6H4BrClO/c7-5-2-1-4(8)3-6(5)9/h1-3,9H
• InChI Key: FMRKYXVZQWHGDA-UHFFFAOYSA-N
• Exact Mass: 205.91341
• Molecular Formula: C6H4BrClO
• Molecular Weight: 207.45
• SMILES: C1=CC(=C(C=C1Cl)O)Br
• Topological: 20.2
• Monoisotopic Mass: 205.91341
• Synonyms: 2-Bromo-5-chlorophenol, 13659-23-9, DTXSID80534671, DTXCID10485460, 603-968-8, Phenol, 2-bromo-5-chloro-, 2-bromo-5-chloro-phenol, MFCD00142870, 5-chloro 2-bromophenol, SCHEMBL897593, FMRKYXVZQWHGDA-UHFFFAOYSA-N, AKOS015890235, CS-W002419, FB64417, SY024323, DB-030829, EN300-126714

Application

2-Bromo-5-chlorophenol serves as a versatile intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty polymers. Its halogenated structure enables participation in palladium-catalyzed cross-coupling reactions to construct complex aromatic systems. Researchers also employ it as a precursor for antimicrobial agents and liquid crystal materials. The compound’s phenolic hydroxyl group allows for further derivatization via esterification or alkylation.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.