Description

2-Bromo-5-chlorobenzotrifluoride (CAS No. 344-65-0) is a high-purity halogenated aromatic compound with the molecular formula C₇H₃BrClF₃. Also known as 1-bromo-4-chloro-2-(trifluoromethyl)benzene, this specialty chemical is widely used in pharmaceutical synthesis, agrochemical production, and advanced material research. The compound features a benzene ring substituted with bromo, chloro, and trifluoromethyl groups, offering unique reactivity for cross-coupling reactions and as a building block in organofluorine chemistry. Our product is rigorously tested to ensure >98% purity (GC) with controlled moisture content, packaged under inert gas to prevent degradation. Available in research quantities (100mg to 100g) with optional certificates of analysis. Store in cool, dry conditions away from light.

Properties

• CAS Number: 344-65-0
• Complexity: 159
• IUPAC Name: 1-bromo-4-chloro-2-(trifluoromethyl)benzene
• InChI: InChI=1S/C7H3BrClF3/c8-6-2-1-4(9)3-5(6)7(10,11)12/h1-3H
• InChI Key: OSTIALFVJOFNPP-UHFFFAOYSA-N
• Exact Mass: 257.90587
• Molecular Formula: C7H3BrClF3
• Molecular Weight: 259.45
• SMILES: C1=CC(=C(C=C1Cl)C(F)(F)F)Br
• Monoisotopic Mass: 257.90587
• Synonyms: 2-Bromo-5-chlorobenzotrifluoride, 344-65-0, 1-Bromo-4-chloro-2-(trifluoromethyl)benzene, DTXSID10187972, DTXCID70110463, 608-994-3, 2-BROMO-5-CHOROBENZOTRIFLUORIDE, MFCD00010308, Benzene, 1-bromo-4-chloro-2-(trifluoromethyl)-, 1-Bromo-4-chloro-2-(trifluoromethyl)benzene;2-Bromo-5-chlorobenzotrifluoride, 2-Bromo-5-chloro-alpha,alpha,alpha-trifluorotoluene, Bromo-5-chlorobenzotrifluoride, SCHEMBL1410268, SBB102207, AKOS005254779, CS-W017778, 2-Bromo-5-chlorobenzotrifluoride, 97%, DS-12675, SY023671, 1-Bromo-4-chloro-2-trifluoromethyl-benzene, DB-048627, B3366, NS00124171, ST50408795, 2-Bromo-5-chloro-|A,|A,|A-trifluorotoluene, F20947, Benzene, 2-bromo-5-chloro-1-(trifluoromethyl)-, EN300-2007174, 1-Bromo-4-chloro-2-(trifluoromethyl)benzene, 2-Bromo-5-chloro-alpha,alpha,alpha-trifluorotoluene

Application

2-Bromo-5-chlorobenzotrifluoride serves as a versatile intermediate in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions for pharmaceutical development. The compound’s electron-deficient aromatic system makes it valuable for synthesizing liquid crystal materials and agrochemical active ingredients. Researchers utilize this building block to introduce both halogen and trifluoromethyl functionalities in drug discovery programs targeting CNS and anti-inflammatory therapies.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (80%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.