Description

2-Bromo-5-chloroaniline (CAS No. 823-57-4) is a high-purity halogenated aniline derivative with the molecular formula C₆H₅BrClN. This compound is a valuable intermediate in organic synthesis, particularly in the pharmaceutical and agrochemical industries. Its IUPAC name, 2-bromo-5-chloroaniline, reflects its precise structural configuration, featuring both bromine and chlorine substituents on the aromatic ring, which enhance its reactivity in cross-coupling reactions and other transformations.

Our product is rigorously tested to ensure ≥98% purity (HPLC/GC), with trace metal analysis available upon request. Supplied as a crystalline solid with a characteristic amine odor, it is packaged under inert gas to maintain stability. Ideal for researchers developing novel active pharmaceutical ingredients (APIs), ligands, or specialty chemicals. Technical data sheets (TDS) and material safety data sheets (MSDS) are provided with every order.

Properties

• CAS Number: 823-57-4
• Complexity: 99.1
• IUPAC Name: 2-bromo-5-chloro-aniline
• InChI: InChI=1S/C6H5BrClN/c7-5-2-1-4(8)3-6(5)9/h1-3H,9H2
• InChI Key: NLEZSQHAFMZAGU-UHFFFAOYSA-N
• Exact Mass: 204.92939
• Molecular Formula: C6H5BrClN
• Molecular Weight: 206.47
• SMILES: C1=CC(=C(C=C1Cl)N)Br
• Topological: 26
• Monoisotopic Mass: 204.92939
• Synonyms: 2-Bromo-5-chloroaniline, 823-57-4, 2-Bromo-5-chlorobenzenamine, DTXSID20461932, DTXCID10412751, 617-321-2, BENZENAMINE, 2-BROMO-5-CHLORO-, 2-Bromo-5-chloro-phenylamine, MFCD00672942, EN300-105774, Bromo-5-chloroaniline, 6-bromo-3-chloroaniline, Aniline, 2-bromo-5-chloro, SCHEMBL110294, (2-bromo-5-chlorophenyl)amine, CHEMBL4947635, SCHEMBL27321267, BDBM625969, AB2685, AKOS015835135, CS-W007760, PS-3358, SB78217, SY020718, DB-010964, B3182

Application

2-Bromo-5-chloroaniline serves as a key building block in Suzuki-Miyaura and Buchwald-Hartwig coupling reactions to synthesize biaryl structures for drug discovery. It is utilized in the preparation of herbicides and fungicides due to its halogenated aromatic core. Researchers also employ it to develop dyes and photoactive materials for optoelectronic applications.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P321, P330, P332+P317, P337+P317, P362+P364, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.