Description

2-Bromo-5-chloro-1,3-difluorobenzene (CAS No. 883546-16-5) is a high-purity halogenated aromatic compound with the molecular formula C₆H₂BrClF₂. This specialty chemical is meticulously synthesized for researchers and industrial scientists requiring precise intermediates in organic synthesis, pharmaceutical development, and materials science. Its unique structure, featuring bromine and chlorine substituents on a difluorobenzene backbone, enables selective functionalization in cross-coupling reactions, nucleophilic substitutions, and as a building block for advanced agrochemicals or liquid crystals. Available in rigorously controlled batches (≥98% purity by GC), this compound is supplied in amber glass vials under inert atmosphere to ensure stability. Technical data including ¹H/¹³C NMR spectra and GC-MS chromatograms are provided with each lot. Store at 2-8°C in a dry environment.

Properties

• CAS Number: 883546-16-5
• Complexity: 110
• IUPAC Name: 2-bromo-5-chloro-1,3-difluoro-benzene
• InChI: InChI=1S/C6H2BrClF2/c7-6-4(9)1-3(8)2-5(6)10/h1-2H
• InChI Key: OUMNGNRBHZGAMH-UHFFFAOYSA-N
• Exact Mass: 225.89965
• Molecular Formula: C6H2BrClF2
• Molecular Weight: 227.43
• SMILES: C1=C(C=C(C(=C1F)Br)F)Cl
• Monoisotopic Mass: 225.89965
• Synonyms: 2-bromo-5-chloro-1,3-difluorobenzene, 883546-16-5, 4-bromo-1-chloro-3,5-difluorobenzene, 1-Bromo-4-chloro-2,6-difluorobenzene, 4-Chloro-2,6-difluorobromobenzene, MFCD06798002, 4-Bromo-3,5-difluorochlorobenzene;2-Bromo-5-chloro-1,3-difluorobenzene, 3,5-DIFLUORO-4-BROMO-CHLOROBENZENE, SCHEMBL18073886, DTXSID30375753, Bromo-5-chloro-1,3-difluorobenzene, CK2350, AKOS005259920, AS-18068, SY025004, DB-057062, CS-0099445

Application

This compound serves as a versatile precursor in Suzuki-Miyaura and Buchwald-Hartwig coupling reactions for constructing complex biaryl systems. Its electron-deficient aromatic ring facilitates nucleophilic aromatic substitutions in pharmaceutical intermediates, particularly for fluorinated drug candidates. The simultaneous presence of bromine and chlorine allows sequential functionalization, making it valuable in material science for designing organic semiconductors or liquid crystal displays (LCDs).

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.