Description

Description

2-Bromo-4,6-difluoroanisole (CAS No. 202865-59-6) is a high-purity halogenated aromatic compound with the molecular formula C₇H₅BrF₂O. Also known as 1-bromo-3,5-difluoro-2-methoxybenzene by IUPAC nomenclature, this specialty chemical is characterized by its bromo- and difluoro-substituted anisole structure, making it a valuable intermediate in organic synthesis and pharmaceutical research. Its unique electronic properties and reactivity profile enable selective functionalization in cross-coupling reactions, nucleophilic substitutions, and as a precursor for advanced materials. Supplied as a clear to pale-yellow liquid (or low-melting solid) with ??95% purity (GC), it is packaged under inert gas to ensure stability. Ideal for researchers developing agrochemicals, liquid crystals, or bioactive molecules requiring precise halogenated building blocks. Storage recommendation: 2-8??C in a tightly sealed container away from light and moisture.

Application

2-Bromo-4,6-difluoroanisole serves as a versatile synthon in medicinal chemistry for introducing bromo- and difluoromethoxy motifs into drug candidates, particularly in CNS-targeting compounds. It is employed in Suzuki-Miyaura coupling reactions to create biaryl scaffolds common in kinase inhibitors. The electron-withdrawing fluorine atoms enhance reactivity in SNAr reactions for constructing heterocyclic systems. Additionally, this compound finds use in materials science as a monomer for fluorine-containing polymers with enhanced thermal stability.

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