Description

2-Bromo-4-trifluoromethylaniline (CAS No. 57946-63-1) is a high-purity aromatic amine derivative with the molecular formula C₇H₅BrF₃N. This compound features a bromo substituent at the 2-position and a trifluoromethyl group at the 4-position of the aniline ring, making it a versatile intermediate for advanced organic synthesis. Ideal for researchers and pharmaceutical chemists, this product is rigorously tested to ensure ≥98% purity (HPLC/GC) and is supplied as a crystalline solid with excellent stability under recommended storage conditions (2-8°C, inert atmosphere). Suitable for use in Suzuki couplings, nucleophilic substitutions, and as a building block for agrochemicals and bioactive molecules. Available in scalable quantities from milligrams to kilograms with customizable packaging options.

Properties

• CAS Number: 57946-63-1
• Complexity: 159
• IUPAC Name: 2-bromo-4-(trifluoromethyl)aniline
• InChI: InChI=1S/C7H5BrF3N/c8-5-3-4(7(9,10)11)1-2-6(5)12/h1-3H,12H2
• InChI Key: QKRJIXSZTKOFTD-UHFFFAOYSA-N
• Exact Mass: 238.95575
• Molecular Formula: C7H5BrF3N
• Molecular Weight: 240.02
• SMILES: C1=CC(=C(C=C1C(F)(F)F)Br)N
• Topological: 26
• Monoisotopic Mass: 238.95575
• Synonyms: 57946-63-1, 2-Bromo-4-trifluoromethylaniline, EINECS 261-035-7, DTXSID60206667, BTFMA, DTXCID90129158, 261-035-7, 2-Bromo-4-(trifluoromethyl)aniline, 4-Amino-3-bromobenzotrifluoride, Benzenamine, 2-bromo-4-(trifluoromethyl)-, MFCD00042150, 3-BROMO-4-AMINOBENZOTRIFLUORIDE, 2-bromo-4-(trifluoromethyl)phenylamine, 2-bromo-4-trifluoromethyl-phenylamine, VJ45J9GV4U, SCHEMBL40549, 2-bromo-4-trifluoromethyl aniline, 2-Bromo-4-trifluoromethylphenylamine, SBB000789, 2-Bromo-4-(trifluoromethyl)aniline #, AKOS000182255, 2-Bromo-4-(trifluoromethyl)benzenamine, AB01890, AC-2322, AC-3662, CS-W004796, PS-7589, 2-Bromo-4-(trifluoromethyl)aniline, 97%, DB-024144, DB-053132, NS00054472, ST45028436, EN300-84933, Z317054112, 2-Bromo-4-(trifluoromethyl)aniline;4-Amino-3-bromobenzotrifluoride, InChI=1/C7H5BrF3N/c8-5-3-4(7(9,10)11)1-2-6(5)12/h1-3H,12H

Application

2-Bromo-4-trifluoromethylaniline serves as a key precursor in the synthesis of trifluoromethyl-substituted heterocycles and pharmaceuticals. It is widely employed in cross-coupling reactions to construct complex molecules for drug discovery. The compound’s electron-withdrawing groups enhance reactivity in palladium-catalyzed aminations, making it valuable for material science and agrochemical applications.

Safety and Hazards

GHS Hazard Statements

• H302 (15.2%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (15.2%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (87%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (15.2%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (15.2%)
• STOT SE 3 (87%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.