Description

2-Bromo-4-(trifluoromethoxy)aniline (CAS No. 175278-17-8) is a high-purity aromatic amine derivative with the molecular formula C₇H₅BrF₃NO. This compound features a bromo-substituted aniline core with a trifluoromethoxy functional group, making it a versatile intermediate for pharmaceutical, agrochemical, and material science applications. Its unique structure enables reactivity in coupling reactions, nucleophilic substitutions, and as a precursor for heterocyclic synthesis. Supplied at ≥98% purity, this product is rigorously tested via HPLC, GC, and NMR to ensure consistency for research and industrial use. Store under inert conditions (2-8°C) to maintain stability. Available in quantities from milligrams to kilograms with custom packaging options.

Properties

• CAS Number: 175278-17-8
• Complexity: 176
• IUPAC Name: 2-bromo-4-(trifluoromethoxy)aniline
• InChI: InChI=1S/C7H5BrF3NO/c8-5-3-4(1-2-6(5)12)13-7(9,10)11/h1-3H,12H2
• InChI Key: ROSTYHNIIDIBEG-UHFFFAOYSA-N
• Exact Mass: 254.95066
• Molecular Formula: C7H5BrF3NO
• Molecular Weight: 256.02
• SMILES: C1=CC(=C(C=C1OC(F)(F)F)Br)N
• Topological: 35.3
• Monoisotopic Mass: 254.95066
• Synonyms: 2-Bromo-4-(trifluoromethoxy)aniline, 175278-17-8, 2-Bromo-4-trifluoromethoxyaniline, DTXSID10350866, DTXCID50301933, 629-119-1, Benzenamine, 2-bromo-4-(trifluoromethoxy)-, MFCD00203478, 2-bromo-4-(trifluoromethoxy)phenylamine, 2-Bromo-4-trifluoromethoxy-phenylamine, SCHEMBL604236, 2-bromo-4(trifluoromethoxy)aniline, SBB101656, AKOS005063497, CS-W012568, PS-7408, SY014268, 2-Bromo-4-(trifluoromethoxy)aniline, 98%, DB-023779, B3799, ST50307890, EN300-118953, InChI=1/C7H5BrF3NO/c8-5-3-4(1-2-6(5)12)13-7(9,10)11/h1-3H,12H, Benzenamine, 2-bromo-4-(trifluoromethoxy)-; 2-Bromo-4-(trifluoromethoxy)benzenamine; 2-Bromo-4-(trifluoromethyloxy)aniline; 2-Bromo-4-trifluoromethoxyaniline

2-Bromo-4-(trifluoromethoxy)aniline serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates. It is employed in agrochemical research for developing herbicides and pesticides due to its halogenated aromatic structure. The compound also finds use in materials science for creating advanced polymers and liquid crystals. Handle with standard aromatic amine precautions under fume hoods.

Safety and Hazards

GHS Hazard Statements

• H315 (97.6%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (95.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (97.6%)
• Eye Irrit. 2 (97.6%)
• STOT SE 3 (95.2%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.