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Atomfair 2-Bromo-4-fluorobenzoic acid C7H4BrFO2

Description 2-Bromo-4-fluorobenzoic acid (CAS No. 146328-85-0) is a high-purity halogenated benzoic acid derivative with the molecular formula C7H4BrFO2. This compound is a valuable building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its structure features both bromine and fluorine substituents, offering unique reactivity for cross-coupling reactions, nucleophilic substitutions, and metal-catalyzed transformations. The product is supplied as a white to off-white crystalline powder with ??98% purity (HPLC), ensuring consistent performance in sensitive applications. Ideal for use in Suzuki-Miyaura couplings, Buchwald-Hartwig aminations, and other palladium-mediated reactions. Packaged under inert gas to maintain stability and stored at 2-8??C for prolonged shelf…

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Description

Description

2-Bromo-4-fluorobenzoic acid (CAS No. 146328-85-0) is a high-purity halogenated benzoic acid derivative with the molecular formula C7H4BrFO2. This compound is a valuable building block in organic synthesis, particularly in pharmaceutical and agrochemical research. Its structure features both bromine and fluorine substituents, offering unique reactivity for cross-coupling reactions, nucleophilic substitutions, and metal-catalyzed transformations. The product is supplied as a white to off-white crystalline powder with ??98% purity (HPLC), ensuring consistent performance in sensitive applications. Ideal for use in Suzuki-Miyaura couplings, Buchwald-Hartwig aminations, and other palladium-mediated reactions. Packaged under inert gas to maintain stability and stored at 2-8??C for prolonged shelf life. Available in research quantities (100mg-10g) with optional certificates of analysis (CoA) upon request.

  • CAS No: 146328-85-0
  • Molecular Formula: C7H4BrFO2
  • Molecular Weight: 219.01
  • Exact Mass: 217.93787
  • Monoisotopic Mass: 217.93787
  • IUPAC Name: 2-bromo-4-fluorobenzoic acid
  • SMILES: C1=CC(=C(C=C1F)Br)C(=O)O
  • Synonyms: 2-Bromo-4-fluorobenzoic acid, 1006-41-3, RRKPMLZRLKTDQV-UHFFFAOYSA-, 600-118-8, inchi=1/c7h4brfo2/c8-6-3-4(9)1-2-5(6)7(10)11/h1-3h,(h,10,11)

Application

2-Bromo-4-fluorobenzoic acid serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates. Its dual halogen functionality enables precise structural modifications in medicinal chemistry programs. The compound is frequently employed in the development of kinase inhibitors, anti-inflammatory agents, and CNS-targeting molecules. Researchers utilize this building block to introduce both fluorine and bromine motifs into lead compounds during structure-activity relationship (SAR) studies.

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