Description

2-Bromo-3,5-dichloropyridine (CAS No. 14482-51-0) is a high-purity halogenated pyridine derivative widely utilized in pharmaceutical and agrochemical research. With the molecular formula C₅H₂BrCl₂N, this compound serves as a versatile building block for synthesizing complex heterocyclic structures. Its reactive bromo and chloro substituents enable selective cross-coupling reactions, nucleophilic substitutions, and metal-catalyzed transformations. Available in ≥95% purity (GC), it is supplied as a white to off-white crystalline powder with excellent stability under recommended storage conditions (2-8°C, inert atmosphere). Suitable for GMP applications, this intermediate is rigorously tested by HPLC, NMR, and MS to meet stringent research requirements. Packaging options range from 1g to 1kg with custom bulk quantities available.

Properties

• CAS Number: 14482-51-0
• Complexity: 101
• IUPAC Name: 2-bromo-3,5-dichloro-pyridine
• InChI: InChI=1S/C5H2BrCl2N/c6-5-4(8)1-3(7)2-9-5/h1-2H
• InChI Key: QCKPJWDIDCGQRB-UHFFFAOYSA-N
• Exact Mass: 224.87477
• Molecular Formula: C5H2BrCl2N
• Molecular Weight: 226.88
• SMILES: C1=C(C=NC(=C1Cl)Br)Cl
• Topological: 12.9
• Monoisotopic Mass: 224.87477
• Synonyms: 2-Bromo-3,5-dichloropyridine, 14482-51-0, DTXSID90355733, DTXCID60306792, 672-535-3, 3,5-Dichloro-2-Bromopyridine, Pyridine, 2-bromo-3,5-dichloro-, MFCD00233990, 2-Bromo-3,5-dichloro-pyridine, 2-bromo-3,5-dichloropyridin, SCHEMBL544483, BCP22111, RB1046, SBB039005, AKOS000267456, AB05062, AC-9472, CS-W007790, GS-6730, SY012471, 2-Bromo-3,5-dichloropyridine, AldrichCPR, DB-020595, B3734, ST50211885, EN300-142157, AC-907/25004316

2-Bromo-3,5-dichloropyridine is primarily employed as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and crop protection agents. Researchers leverage its halogenated structure for Suzuki-Miyaura couplings to create biaryl scaffolds in drug discovery. The compound also finds use in material science for developing liquid crystals and conductive polymers. Its reactivity enables precise modifications for structure-activity relationship (SAR) studies in medicinal chemistry programs.

Safety and Hazards

GHS Hazard Statements

• H302 (25%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (25%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (25%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (75%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (25%)
• Acute Tox. 4 (25%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (25%)
• STOT SE 3 (75%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.