Description

2-Bromo-3-fluoropyridine (CAS No. 40273-45-8) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₃BrFN. This heteroaromatic compound is a versatile building block in pharmaceutical, agrochemical, and materials science research. Its unique structure, featuring both bromine and fluorine substituents on the pyridine ring, enables selective functionalization via cross-coupling reactions (e.g., Suzuki, Stille) or nucleophilic substitutions. Available in ≥98% purity (GC), it is supplied as a clear to pale-yellow liquid with strict quality control via HPLC, NMR, and GC-MS analysis. Store under inert atmosphere at 2-8°C to maintain stability. Suitable for use in high-throughput screening, medicinal chemistry, and as a precursor for fluorinated liquid crystals or ligands.

Properties

• CAS Number: 40273-45-8
• Complexity: 78.8
• IUPAC Name: 2-bromo-3-fluoro-pyridine
• InChI: InChI=1S/C5H3BrFN/c6-5-4(7)2-1-3-8-5/h1-3H
• InChI Key: IFGLECYAEGYLSJ-UHFFFAOYSA-N
• Exact Mass: 174.94329
• Molecular Formula: C5H3BrFN
• Molecular Weight: 175.99
• SMILES: C1=CC(=C(N=C1)Br)F
• Topological: 12.9
• Monoisotopic Mass: 174.94329
• Synonyms: 2-Bromo-3-fluoropyridine, 40273-45-8, DTXSID10376465, DTXCID70327493, 675-562-9, MFCD04114128, Pyridine, 2-bromo-3-fluoro-, 2-bromo-3-fluoro-pyridine, 2-bromo-fluoropyridine, bromo-3-fluoro pyrdine, 2-bromo-3-fluoropyrdine, 3-fluoro-2-bromopyridine, SCHEMBL230461, SCHEMBL318965, SCHEMBL1988951, SCHEMBL28602519, IFGLECYAEGYLSJ-UHFFFAOYSA-N, BCP22167, RB1083, SBB089105, AKOS005063962, AC-6267, CS-W001136, PB14380, PS-8594, SY019785, DB-027841, A6739, B3666, EN300-102017, F0001-4310, Z997724396

Application

2-Bromo-3-fluoropyridine serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly kinase inhibitors and CNS-targeting compounds. Its bromine moiety facilitates palladium-catalyzed couplings for constructing complex heterocycles, while the fluorine enhances metabolic stability in drug candidates. Researchers also employ it to develop agrochemicals and electronic materials requiring halogenated pyridine cores. The compound’s reactivity is exploited in Suzuki-Miyaura and Buchwald-Hartwig amination reactions.

Safety and Hazards

GHS Hazard Statements

• H301 (10.9%): Toxic if swallowed [Danger Acute toxicity, oral]
• H311 (10.9%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (10.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (10.9%)
• Acute Tox. 3 (10.9%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (10.9%)
• STOT SE 3 (97.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.