Description

2-Bromo-1-indanol (CAS No. 5400-80-6) is a high-purity brominated indanol derivative with the molecular formula C₉H₉BrO. This compound, also known by its IUPAC name 2-bromo-2,3-dihydro-1H-inden-1-ol, is a versatile chiral building block widely used in organic synthesis and pharmaceutical research. The presence of both bromine and hydroxyl functional groups on the indane scaffold makes it a valuable intermediate for nucleophilic substitutions, cyclizations, and asymmetric transformations.

Our product is rigorously tested to ensure ≥98% purity (HPLC/GC) and is supplied as a white to off-white crystalline solid. It is packaged under inert gas to ensure stability and longevity. Ideal for medicinal chemistry, catalysis, and material science applications, this compound offers excellent reactivity for constructing complex heterocycles and bioactive molecules.

Key synonyms include: 2-Bromoindan-1-ol, 1-Hydroxy-2-bromoindan.

Properties

• CAS Number: 5400-80-6
• Complexity: 148
• IUPAC Name: 2-bromoindan-1-ol
• InChI: InChI=1S/C9H9BrO/c10-8-5-6-3-1-2-4-7(6)9(8)11/h1-4,8-9,11H,5H2
• InChI Key: RTESDSDXFLYAKZ-UHFFFAOYSA-N
• Exact Mass: 211.98368
• Molecular Formula: C9H9BrO
• Molecular Weight: 213.07
• SMILES: C1C(C(C2=CC=CC=C21)O)Br
• Topological: 20.2
• Monoisotopic Mass: 211.98368
• Synonyms: 2-Bromo-1-indanol, 5400-80-6, 2-bromo-2,3-dihydro-1H-inden-1-ol, 2-Bromoindan-1-ol, 1-Hydroxy-2-bromoindan, 2-Bromo-1-hydroxyindane, Indene bromohydrin, trans-2-Bromo-1-indanol, MFCD00003798, 1H-Inden-1-ol, 2-bromo-2,3-dihydro-, 1-Indanol, 2-bromo-, NSC-10389, rac-(1R,2S)-2-bromo-2,3-dihydro-1H-inden-1-ol, cis, 2-Bromo-1-hydroxyhydrindene, NSC10389, EINECS 226-442-6, (1R,2S)-2-bromo-2,3-dihydro-1H-inden-1-ol, 1H-Inden-1-ol, 2-bromo-2,3-dihydro-, (1R,2R)-rel-, SCHEMBL383562, 4E68V72BZA, DTXSID701316516, CKA98460, STR03672, NSC 10389, SBB058660, AKOS000120550, AKOS016050383, FB67931, SY048498, 2-Bromo-1-hydroxyindane;Indene bromohydrin, DB-052453, DB-059033, B1300, CS-0155928, NS00044205, ST50308169, EN300-20982, 2P-744, A10217, AP-406/41269981, Z104485720

Application

2-Bromo-1-indanol serves as a key intermediate in the synthesis of indane-based pharmaceuticals, including serotonin receptor modulators and enzyme inhibitors. Its chiral structure makes it valuable for asymmetric catalysis and the preparation of enantiomerically pure compounds. Researchers also utilize it in cross-coupling reactions to introduce indane motifs into agrochemicals and functional materials.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (83.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (83.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.