Description

2-Bromo-1-(3,5-difluorophenyl)ethanone (CAS No. 220607-75-0) is a high-purity brominated aromatic ketone with the molecular formula C₈H₅BrF₂O. This compound is characterized by its reactive bromoacetyl group and electron-withdrawing difluorophenyl moiety, making it a valuable intermediate in organic synthesis, pharmaceutical research, and materials science. It is supplied as a crystalline solid with strict quality control to ensure consistency in reactivity and purity. Ideal for nucleophilic substitution reactions, cross-coupling chemistry, and as a precursor for heterocyclic compounds. Store in a cool, dry place under inert conditions to maintain stability.

Properties

• CAS Number: 220607-75-0
• Complexity: 164
• IUPAC Name: 2-bromo-1-(3,5-difluorophenyl)ethanone
• InChI: InChI=1S/C8H5BrF2O/c9-4-8(12)5-1-6(10)3-7(11)2-5/h1-3H,4H2
• InChI Key: CJEGSZFRYLCTLK-UHFFFAOYSA-N
• Exact Mass: 233.94918
• Molecular Formula: C8H5BrF2O
• Molecular Weight: 235.02
• SMILES: C1=C(C=C(C=C1F)F)C(=O)CBr
• Topological: 17.1
• Monoisotopic Mass: 233.94918
• Synonyms: 220607-75-0, 2-bromo-1-(3,5-difluorophenyl)ethanone, DTXSID50380869, DTXCID30331894, 3,5-DIFLUOROPHENACYL BROMIDE, 2-bromo-3′,5′-difluoroacetophenone, 2-bromo-1-(3,5-difluorophenyl)-1-ethanone, MFCD03094245, 2-BROMO-3,5-DIFLUOROACETOPHENONE, Ethanone, 2-bromo-1-(3,5-difluorophenyl)-, 1-(3,5-difluorophenyl)-2-bromoethan-1-one, 2-bromo-1-(3,5-difluorophenyl)ethan-1-one, 3,5-difluorophenacylbromide, SCHEMBL976560, 3′,5′-Difluorophenacyl bromide, 3′,5′-Difluorophenacyl bromide;, CJEGSZFRYLCTLK-UHFFFAOYSA-N, ALBB-034444, CS-M0153, CL8630, SBB068925, AKOS015836060, AS-46061, SY081438, 2-bromo-1-(3,5-difluorophenyl) ethanone, 2-bromo-1-(3,5-difluorophenyl)-ethanone, 2-bromo-1-(3,5-difluoro-phenyl)-ethanone, DB-011971, EN300-182828

Application

2-Bromo-1-(3,5-difluorophenyl)ethanone is widely used as a key building block in the synthesis of pharmaceuticals, agrochemicals, and specialty materials. Its reactive bromoacetyl group facilitates efficient nucleophilic substitutions, enabling the introduction of the 3,5-difluorophenyl motif into complex molecules. Researchers employ this compound in the development of kinase inhibitors, fluorinated analogs, and bioactive scaffolds. It is also utilized in materials science for the preparation of advanced polymers and liquid crystals.

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