Description

2-Amino-6-fluorobenzonitrile (CAS No. 77326-36-4) is a high-purity fluorinated aromatic compound with the molecular formula C₇H₅FN₂. This specialized chemical features both an amino (–NH₂) and a cyano (–CN) functional group adjacent to a fluorine substituent on a benzene ring, making it a versatile intermediate for pharmaceutical, agrochemical, and materials science research. Its unique structure enables participation in nucleophilic substitution, condensation, and cyclization reactions. Available in ≥98% purity (HPLC/GC), this compound is supplied as a crystalline solid with strict quality control to ensure batch-to-batch consistency. Store under inert conditions at 2-8°C to maintain stability. Ideal for synthesizing fluorinated heterocycles or as a building block for bioactive molecules. MSDS and analytical certificates provided.

Properties

• CAS Number: 77326-36-4
• Complexity: 160
• IUPAC Name: 2-amino-6-fluoro-benzonitrile
• InChI: InChI=1S/C7H5FN2/c8-6-2-1-3-7(10)5(6)4-9/h1-3H,10H2
• InChI Key: IQUNZGOZUJITBJ-UHFFFAOYSA-N
• Exact Mass: 136.04367633
• Molecular Formula: C7H5FN2
• Molecular Weight: 136.13
• SMILES: C1=CC(=C(C(=C1)F)C#N)N
• Topological: 49.8
• Monoisotopic Mass: 136.04367633
• Synonyms: 2-Amino-6-fluorobenzonitrile, 77326-36-4, EC 616-451-7, DTXSID10335032, DTXCID60286121, 616-451-7, Benzonitrile, 2-amino-6-fluoro-, MFCD00015477, 6-Fluoroanthranilonitrile, 2-amino-6-fluorobenzenecarbonitrile, 6-Fluoro-2-aminobenzonitrile, 2-amino-6-fluoro-benzonitrile, 2-Amino-6-fluorobenzo-nitrile, 6-Amino-2-fluorobenzenecarbonitrile; 6-Fluoro-2-aminobenzonitrile; 2-Cyano-3-fluorophenylamine; 2-Amino-6-fluoro-benzonitrile;, MKH6CY3HWJ, 2-Cyano-3-fluoroaniline, SCHEMBL165576, SCHEMBL4051815, 2-amino-6-fluoro-benzo-nitrile, CHEMBL5411612, 6-amino-2-fluorobenzenecarbonitrile, BBC52456, BCP14112, 2-Amino-6-fluorobenzonitrile, 99%, BBL027814, SBB048092, STK503755, AKOS005145803, AC-2314, BH-0415, CS-W001178, FA17660, DB-005964, A2344, NS00002324, ST50946641, EN300-24406, 6-Amino-2-fluorobenzenecarbonitrile;6-Fluoro-2-aminobenzonitrile, InChI=1/C7H5FN2/c8-6-2-1-3-7(10)5(6)4-9/h1-3H,10H, 0IF

Application

2-Amino-6-fluorobenzonitrile serves as a key precursor in the synthesis of fluorinated quinazolines and other nitrogen-containing heterocycles with potential pharmacological activity. Researchers utilize it to develop kinase inhibitors and antimicrobial agents due to its dual functional group reactivity. The compound’s fluorine moiety enhances metabolic stability in drug candidates, making it valuable for medicinal chemistry optimization studies.

Safety and Hazards

GHS Hazard Statements

• H302 (18.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (17%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (24.5%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (98.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (18.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (11.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P262, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (18.9%)
• Acute Tox. 3 (17%)
• Skin Irrit. 2 (24.5%)
• Eye Irrit. 2A (98.1%)
• Acute Tox. 4 (18.9%)
• STOT SE 3 (11.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.