Description

2-Amino-5-(trifluoromethyl)pyridine (CAS No. 74784-70-6) is a high-purity, versatile heterocyclic compound with the molecular formula C₆H₅F₃N₂. This fine chemical features a pyridine backbone substituted with an amino group at the 2-position and a trifluoromethyl group at the 5-position, offering unique electronic and steric properties critical for pharmaceutical, agrochemical, and materials science applications. The presence of both electron-donating (amino) and electron-withdrawing (trifluoromethyl) groups makes this compound an excellent building block for drug discovery, catalyst design, and functional material synthesis. Our product is rigorously tested to ensure ≥97% purity (GC) and is supplied as a white to off-white crystalline powder with excellent shelf stability. Suitable for nucleophilic substitution reactions, metal-catalyzed cross-couplings, and as a ligand precursor. Packaged under inert gas in amber glass vials or bulk quantities with customizable options for industrial-scale procurement.

Properties

• CAS Number: 74784-70-6
• Complexity: 134
• IUPAC Name: 5-(trifluoromethyl)pyridin-2-amine
• InChI: InChI=1S/C6H5F3N2/c7-6(8,9)4-1-2-5(10)11-3-4/h1-3H,(H2,10,11)
• InChI Key: RSGVKIIEIXOMPY-UHFFFAOYSA-N
• Exact Mass: 162.04048265
• Molecular Formula: C6H5F3N2
• Molecular Weight: 162.11
• SMILES: C1=CC(=NC=C1C(F)(F)F)N
• Topological: 38.9
• Monoisotopic Mass: 162.04048265
• Synonyms: 2-Amino-5-(trifluoromethyl)pyridine, 623-444-2, 74784-70-6, 5-(trifluoromethyl)pyridin-2-amine, 2-Amino-5-trifluoromethylpyridine, 5-(Trifluoromethyl)-2-pyridinamine, MFCD00042164, 5-(trifluoromethyl)-2-pyridylamine, EN300-114757, 2-PYRIDINAMINE, 5-(TRIFLUOROMETHYL)-, 5-trifluoromethyl-pyridin-2-ylamine, 2-Amino-5-Trifluoromethyl Pyridine, 5-(Trifluoromethyl)-2-pyridinamine; 5-(Trifluoromethyl)pyridine-2ylamine; 5-Trifluoromethyl-2-aminopyridine; (5-Trifluoromethylpyridin-2-yl)amine;, 5-(trifluoromethyl)pyridine-2-amine, SCHEMBL177728, SCHEMBL2877340, SCHEMBL28713868, 5-trifluoromethylpyridin-2-amine, RSGVKIIEIXOMPY-UHFFFAOYSA-, 5-trifluoromethyl-2-aminopyridine, DTXSID70352866, BDBM625988, 2-amino-5 -trifluoromethylpyridine, 2-amino-5-trifluoromethyl-pyridine, BCP11413, 5-(trifluoromethyl)-2-aminopyridine, 5-trifluoromethyl-pyridine-2-ylamine, BBL011556, CL8872, SBB005500, STL146691, AKOS000265599, AC-2715, CS-W007857, FS-1068, PB24559, SY002646, 2-Amino-5-(trifluoromethyl)pyridine, 97%, DB-005178, A1968, ST50408268, AF-399/32352004, Q27453673, InChI=1/C6H5F3N2/c7-6(8,9)4-1-2-5(10)11-3-4/h1-3H,(H2,10,11), 3B0

2-Amino-5-(trifluoromethyl)pyridine serves as a key intermediate in the synthesis of biologically active molecules, particularly in antiviral and anticancer drug development. Its trifluoromethyl group enhances metabolic stability and lipophilicity in pharmaceutical candidates. The compound is widely employed in Suzuki-Miyaura couplings to create bipyridine ligands for catalytic systems. In materials science, it functions as a precursor for fluorinated liquid crystals and OLED materials. Researchers also utilize it to modify polymer backbones for enhanced chemical resistance.

Safety and Hazards

GHS Hazard Statements

• H301 (96%): Toxic if swallowed [Danger Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (98.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (96%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (98.7%)
• STOT SE 3 (98.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.