Description

2-Amino-5-fluoropyridine (CAS No. 21717-96-4) is a high-purity fluorinated pyridine derivative with the molecular formula C₅H₅FN₂. This compound is a versatile building block in pharmaceutical and agrochemical synthesis, offering exceptional reactivity due to the presence of both an amino group and a fluorine substituent on the pyridine ring. It is supplied as a crystalline solid with a purity of ≥97%, ensuring consistency for research and industrial applications. Ideal for nucleophilic substitution reactions, cross-coupling reactions, and as a precursor for heterocyclic compounds. Packaged under inert conditions to maintain stability and shelf life. Suitable for use in medicinal chemistry, material science, and as a ligand in catalysis.

Properties

• CAS Number: 21717-96-4
• Complexity: 76.8
• IUPAC Name: 5-fluoropyridin-2-amine
• InChI: InChI=1S/C5H5FN2/c6-4-1-2-5(7)8-3-4/h1-3H,(H2,7,8)
• InChI Key: YJTXQLYMECWULH-UHFFFAOYSA-N
• Exact Mass: 112.04367633
• Molecular Formula: C5H5FN2
• Molecular Weight: 112.10
• SMILES: C1=CC(=NC=C1F)N
• Topological: 38.9
• Monoisotopic Mass: 112.04367633
• Synonyms: 2-Amino-5-fluoropyridine, 627-638-8, 21717-96-4, 5-fluoropyridin-2-amine, 5-Fluoro-2-pyridinamine, 21917-96-4, 5-Fluoro-2-pyridineamine, 5-fluoro-pyridin-2-ylamine, 2-PYRIDINAMINE, 5-FLUORO-, MFCD01861120, 5-fluoro-2-pyridylamine, 5-fluoranylpyridin-2-amine, 5-FLUORO-2-AMINOPYRIDINE, 5-fluoropyridimine, U1Q, 5-luoropyridin-2-amine, 2-amino-5-fluoropryidine, 5-fluoropyridine-2-amine, 5-fluoropyridin-2-ylamine, 2-amino-5-fluoro pyridine, 2-amino-5-fluoro-pyridine, L2H46AT7ZN, (5-Fluoropyridin-2-yl)amine, SCHEMBL103719, SCHEMBL932114, 5-Fluoropyridin-2(1H)-imine, SCHEMBL2642791, SCHEMBL13174783, SCHEMBL15124262, DTXSID20944331, 2-Amino-5-fluoropyridine, 97%, CHEBI:194590, ALBB-006132, BCP26321, CS-B0957, SBB013948, STK503733, AKOS005063474, AC-3362, CCG-302493, FA02882, PS-9250, SB10593, BP-21327, SY004383, DB-011839, ST4125595, EN300-26452, 5-Fluoropyridin-2-amine;5-Fluoro-2-pyridineamine, A847702, A1-00453, doi:10.14272/YJTXQLYMECWULH-UHFFFAOYSA-N.1, Z223120142, InChI=1/C5H5FN2/c6-4-1-2-5(7)8-3-4/h1-3H,(H2,7,8

2-Amino-5-fluoropyridine is widely used as an intermediate in the synthesis of active pharmaceutical ingredients (APIs) and specialty chemicals. Its fluorine moiety enhances bioavailability and metabolic stability in drug candidates. Researchers employ it in Suzuki-Miyaura couplings and other palladium-catalyzed reactions. It also serves as a precursor for fluorinated liquid crystals and OLED materials. In agrochemistry, it is utilized to develop novel pesticides and herbicides.

Safety and Hazards

GHS Hazard Statements

• H312 (10.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (10.2%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98%)

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