Description

2-Amino-5-chloro-3-methylpyridine (CAS No. 20712-16-7) is a high-purity heterocyclic organic compound with the molecular formula C₆H₇ClN₂. This specialized chemical, also known by its IUPAC name 5-chloro-3-methylpyridin-2-amine, is a valuable building block in pharmaceutical and agrochemical synthesis. The compound features a pyridine core substituted with an amino group at the 2-position, a chlorine atom at the 5-position, and a methyl group at the 3-position, offering multiple reactive sites for further functionalization.

Our product is rigorously tested to ensure >98% purity (HPLC) and is supplied as a crystalline solid with excellent batch-to-batch consistency. Ideal for medicinal chemistry applications, this intermediate is particularly useful in the development of novel drug candidates and biologically active compounds. The product is packaged under inert atmosphere to ensure stability and is available in research quantities from milligrams to kilogram scale.

Key Specifications:
– Molecular Weight: 142.59 g/mol
– Appearance: Off-white to light yellow crystalline powder<br- Melting Point: 98-102°C
– Storage: Store at 2-8°C in a tightly sealed container
– Hazard Information: Irritant (GHS07)

Properties

• CAS Number: 20712-16-7
• Complexity: 97.1
• IUPAC Name: 5-chloro-3-methyl-pyridin-2-amine
• InChI: InChI=1S/C6H7ClN2/c1-4-2-5(7)3-9-6(4)8/h2-3H,1H3,(H2,8,9)
• InChI Key: QTZBTBLHYPSFMG-UHFFFAOYSA-N
• Exact Mass: 142.0297759
• Molecular Formula: C6H7ClN2
• Molecular Weight: 142.58
• SMILES: CC1=CC(=CN=C1N)Cl
• Topological: 38.9
• Monoisotopic Mass: 142.0297759
• Synonyms: 2-Amino-5-chloro-3-methylpyridine, DTXSID10325478, DTXCID90276595, 677-103-8, 20712-16-7, 5-chloro-3-methylpyridin-2-amine, 2-Amino-5-chloro-3-picoline, 2-Pyridinamine, 5-chloro-3-methyl-, 2-amino-3-methyl-5-chloropyridine, MFCD00129030, 5-chloro-3-methyl-2-pyridinamine, NSC508755, SCHEMBL119781, 5-chloro-3-methyl-2-pyridylamine, BCP22106, BBL100325, SBB051890, STL553959, AKOS000113885, AB03635, CS-W002399, DS-0718, NSC-508755, AC-24908, SY019853, TS-03584, DB-027766, A1931, EN300-123166, AN-584/43509539

Application

2-Amino-5-chloro-3-methylpyridine serves as a versatile intermediate in pharmaceutical research, particularly in the synthesis of kinase inhibitors and other nitrogen-containing heterocycles. The compound’s unique substitution pattern makes it valuable for constructing complex molecular architectures in medicinal chemistry. Researchers utilize this building block in the development of potential therapeutic agents targeting various disease pathways. Its chlorine and amino groups provide excellent handles for further derivatization through cross-coupling reactions or nucleophilic substitutions.

Safety and Hazards

GHS Hazard Statements

• H302 (25%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (75%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (25%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (75%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (25%)
• Skin Irrit. 2 (75%)
• Eye Dam. 1 (25%)
• Eye Irrit. 2A (75%)
• STOT SE 3 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.