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Atomfair 2-Amino-5-bromopyridine C5H5BrN2 CAS 1072-97-5

2-Amino-5-bromopyridine (CAS No. 1072-97-5) is a high-purity organic compound with the molecular formula C5H5BrN2, widely used as a versatile intermediate in pharmaceutical synthesis, agrochemical development, and advanced material research. This fine chemical features a pyridine core substituted with an amino group at the 2-position and a bromine atom at the 5-position, enabling diverse functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig). Supplied as a crystalline solid with ≥97% purity (HPLC), it is packaged under inert conditions to ensure stability. Ideal for medicinal chemistry applications, its bromo-aminopyridine scaffold serves as a key building block for kinase inhibitors, heterocyclic APIs, and ligand design.…

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Description

2-Amino-5-bromopyridine (CAS No. 1072-97-5) is a high-purity organic compound with the molecular formula C5H5BrN2, widely used as a versatile intermediate in pharmaceutical synthesis, agrochemical development, and advanced material research. This fine chemical features a pyridine core substituted with an amino group at the 2-position and a bromine atom at the 5-position, enabling diverse functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig). Supplied as a crystalline solid with ≥97% purity (HPLC), it is packaged under inert conditions to ensure stability. Ideal for medicinal chemistry applications, its bromo-aminopyridine scaffold serves as a key building block for kinase inhibitors, heterocyclic APIs, and ligand design. Technical specifications include: molecular weight 173.01 g/mol, melting point 94-98°C, and storage recommendations of 2-8°C in a dry environment. Available in research (100mg-1g), development (5g-25g), and bulk (100g+) quantities with optional custom purity (99%+).

Properties

  • CAS Number: 1072-97-5
  • Complexity: 76.8
  • IUPAC Name: 5-bromopyridin-2-amine
  • InChI: InChI=1S/C5H5BrN2/c6-4-1-2-5(7)8-3-4/h1-3H,(H2,7,8)
  • InChI Key: WGOLHUGPTDEKCF-UHFFFAOYSA-N
  • Exact Mass: 171.96361
  • Molecular Formula: C5H5BrN2
  • Molecular Weight: 173.01
  • SMILES: C1=CC(=NC=C1Br)N
  • Topological: 38.9
  • Monoisotopic Mass: 171.96361
  • Synonyms: 2-Amino-5-bromopyridine, 1072-97-5, 2-Pyridinamine, 5-bromo-, 5-Bromo-2-pyridinamine, 5-Bromo-2-pyridylamine, 5-Bromo-2-aminopyridine, 5-bromopyridin-2-ylamine, EINECS 214-019-9, D5QE8XW52U, Pyridine, 2-amino-5-bromo-, NSC-26282, DTXSID5022144, NSC 26282, DTXCID202144, 5-bromopyridin-2-amine, MFCD00006323, 2-amino-5-bromo pyridine, 5-bromo-pyridin-2-ylamine, F1995-0207, UNII-D5QE8XW52U, NSC26282, amino-5-bromopyridine, 2-Amino5-bromopyridine, 2-amino-5-bromopridine, 2-amino-5-brompyridine, 5-bromopyridine-2-amine, Maybridge1_001149, 2-amino-5 -bromopyridine, 2-amino-5-bromo-pyridine, 5-bromo-2-amino-pyridine, 6-amino-3-bromo-pyridine, 5-bromopyridin-2-yl amine, Cambridge id 5121777, 2-amino, 5-bromo-pyridine, SCHEMBL105422, SCHEMBL4054199, SCHEMBL5071361, SCHEMBL11406306, SCHEMBL22298049, 2-Amino-5-bromopyridine, 97%, HMS544M05, SMSSF-0533077, BCP27587, CS-D1666, STR04388, AC-031, CL0041, SBB003823, STK024650, AKOS000112980, FA00676, FS-1054, PB30536, SB10592, DB-027763, NS00023452, ST45155785, EN300-17910, 5-Bromopyridin-2-amine;5-Bromo-2-aminopyridine, AC-907/34116004, AH-034/32826051, AJ-333/25022117, Q27276127, Z57073814

2-Amino-5-bromopyridine serves as a critical precursor in palladium-catalyzed cross-coupling reactions to construct complex heterocycles for drug discovery programs. Its dual functionality enables sequential derivatization, making it valuable for synthesizing kinase inhibitor cores in oncology research. The compound is also employed in materials science as a ligand precursor for metal-organic frameworks (MOFs) and in agrochemical production as an intermediate for crop protection agents. Researchers utilize its bromopyridine scaffold for structure-activity relationship (SAR) studies in medicinal chemistry.

Safety and Hazards

GHS Hazard Statements

  • H301 (86.4%): Toxic if swallowed [Danger Acute toxicity, oral]
  • H315 (98.8%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (98.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (97.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 3 (86.4%)
  • Skin Irrit. 2 (98.8%)
  • Eye Irrit. 2 (98.8%)
  • STOT SE 3 (97.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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