Description

2-Amino-5-bromo-4-methylpyridine (CAS No. 98198-48-2) is a high-purity brominated pyridine derivative with the molecular formula C₆H₇BrN₂. This heterocyclic compound features an amino group at the 2-position and a bromine substituent at the 5-position, making it a versatile intermediate for pharmaceutical synthesis, agrochemical development, and materials science research. With a purity of ≥98%, it is supplied as a crystalline solid with excellent batch-to-batch consistency. Ideal for nucleophilic substitution reactions, cross-coupling protocols (e.g., Suzuki-Miyaura), and as a building block for bioactive molecules. Store under inert atmosphere at 2-8°C to maintain stability. Available in research quantities up to bulk scale with full analytical documentation (HPLC, NMR, MS).

Properties

• CAS Number: 98198-48-2
• Complexity: 97.1
• IUPAC Name: 5-bromo-4-methyl-pyridin-2-amine
• InChI: InChI=1S/C6H7BrN2/c1-4-2-6(8)9-3-5(4)7/h2-3H,1H3,(H2,8,9)
• InChI Key: JDNCMHOKWINDKI-UHFFFAOYSA-N
• Exact Mass: 185.97926
• Molecular Formula: C6H7BrN2
• Molecular Weight: 187.04
• SMILES: CC1=CC(=NC=C1Br)N
• Topological: 38.9
• Monoisotopic Mass: 185.97926
• Synonyms: 2-Amino-5-bromo-4-methylpyridine, 98198-48-2, DTXSID30355838, DTXCID00306897, 628-174-9, 5-bromo-4-methylpyridin-2-amine, 2-Amino-5-bromo-4-picoline, 2-Amino-4-methyl-5-bromopyridine, MFCD03427660, 5-bromo-4-methyl-2-pyridylamine, 2-Pyridinamine, 5-bromo-4-methyl-, 5-bromo-4-methyl-2-pyridinamine, 5-bromo-4-methyl-2-pyridinylamine, AC-907/34104054, SCHEMBL358348, 2-amino5-bromo-4-methylpyridine, JDNCMHOKWINDKI-UHFFFAOYSA-, 2-Amino-5-bromo4-methylpyridine, 5-bromo-2-amino-4-methylpyridine, 5-bromo-4-methylpyridine-2-amine, 2-amino-4-methyl-5-bromo-pyridine, BCP02995, CS-D1195, 5-bromo-4-methyl-[2]-pyridylamine, BBL100715, CL0030, SBB090524, STL554509, AKOS002664319, AB15088, DS-0503, FS-2466, 2-Amino-5-bromo-4-methylpyridine, 98%, AC-23275, HY-17562, SY007026, DB-023164, A1897, ST50405581, EN300-97677, 2-Amino-5-bromo-4-picoline (2-Amino-5-bromo-4-methylpyridine), InChI=1/C6H7BrN2/c1-4-2-6(8)9-3-5(4)7/h2-3H,1H3,(H2,8,9)

This compound serves as a key precursor in the synthesis of kinase inhibitors and other pharmacologically active pyridine derivatives. Researchers utilize it for developing fluorescent probes due to its electron-rich aromatic system. In material science, it functions as a ligand for transition metal catalysts. The bromine moiety enables efficient palladium-catalyzed cross-coupling reactions for complex molecule assembly.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.