Description

2-Amino-5-bromo-4-methyl-3-nitropyridine (CAS: 100367-40-6) is a high-purity heterocyclic compound with the molecular formula C₆H₆BrN₃O₂. This nitro-substituted pyridine derivative is a versatile intermediate in organic synthesis, particularly in pharmaceutical and agrochemical research. With a bromine substituent at the 5-position and a nitro group at the 3-position, this compound is ideal for nucleophilic substitution reactions, cross-coupling methodologies, and further functionalization. It is supplied as a crystalline solid with ≥95% purity (HPLC), ensuring consistency for sensitive applications. Suitable for use in medicinal chemistry, material science, and as a precursor for complex molecular scaffolds. Store under inert conditions at 2-8°C to maintain stability.

Properties

• CAS Number: 100367-40-6
• Complexity: 184
• IUPAC Name: 5-bromo-4-methyl-3-nitro-pyridin-2-amine
• InChI: InChI=1S/C6H6BrN3O2/c1-3-4(7)2-9-6(8)5(3)10(11)12/h2H,1H3,(H2,8,9)
• InChI Key: KFVGEPWMVKZPND-UHFFFAOYSA-N
• Exact Mass: 230.96434
• Molecular Formula: C6H6BrN3O2
• Molecular Weight: 232.03
• SMILES: CC1=C(C(=NC=C1Br)N)[N+](=O)[O-]
• Topological: 84.7
• Monoisotopic Mass: 230.96434
• Synonyms: 2-Amino-5-bromo-4-methyl-3-nitropyridine, 100367-40-6, DTXSID40428426, DTXCID20379260, 634-469-3, 5-bromo-4-methyl-3-nitropyridin-2-amine, 2-Amino-5-bromo-3-nitro-4-picoline, 2-PYRIDINAMINE, 5-BROMO-4-METHYL-3-NITRO-, MFCD00092197, EN300-134408, 5-Bromo-4-methyl-3-nitropyridin-2-amine; 2-Amino-5-bromo-3-nitro-4-picoline; 5-Bromo-4-methyl-3-nitro-2-pyridinamine; 2-Amino-5-bromo-3-nitro-4-methylpyridine; 2-Amino-5-bromo-4-methyl-3-nitropyridine; 5-Bromo-4-methyl-3-nitropyridin-2-amine, 5-bromo-4-methyl-3-nitro-2-pyridylamine, SCHEMBL203339, KFVGEPWMVKZPND-UHFFFAOYSA-N, BDBM626019, BCP23411, CS-M1656, SBB068997, AKOS007930477, PB17111, AC-23098, DS-13049, SY017447, DB-012252, 2-amino-5-bromo-3-nitro-4-methyl-pyridine, A2988, F1916-8161

2-Amino-5-bromo-4-methyl-3-nitropyridine serves as a key intermediate in the synthesis of biologically active molecules, including potential kinase inhibitors and antimicrobial agents. Its reactive bromo and nitro groups enable facile derivatization via Suzuki-Miyaura or Buchwald-Hartwig couplings. Researchers utilize this compound in the development of fluorescent probes and coordination complexes due to its electron-deficient pyridine core. It is also employed in the preparation of fused heterocycles for drug discovery programs.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.6%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.