Description

Description

2-Amino-3-(trifluoromethyl)benzoic acid (CAS No. 313-12-2) is a high-purity fluorinated aromatic compound with the molecular formula C₈H₆F₃NO₂. This white to off-white crystalline powder is a versatile building block in pharmaceutical and agrochemical synthesis, particularly in the development of active ingredients with enhanced bioavailability and metabolic stability. With a molecular weight of 205.14 g/mol, it features both an amino (-NH₂) and carboxylic acid (-COOH) functional group ortho to a trifluoromethyl (-CF₃) substituent, enabling diverse derivatization opportunities. Our product is analytically validated by HPLC (>98% purity), NMR, and mass spectrometry, and is supplied in amber glass vials under inert atmosphere to ensure long-term stability. Ideal for medicinal chemistry, this compound is packaged in 1g, 5g, and 25g quantities with optional certificates of analysis for GMP applications.

Application

This compound serves as a key intermediate in the synthesis of trifluoromethyl-substituted heterocycles used as kinase inhibitors and antimicrobial agents. The electron-withdrawing CF₃ group enhances binding affinity in drug-receptor interactions while the orthogonal functional groups allow for parallel synthesis approaches. Researchers employ it in Suzuki-Miyaura cross-coupling reactions to create biaryl pharmacophores, particularly in oncology and CNS drug discovery programs.

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