Description

2-Amino-3-fluoropyridine (CAS No. 21717-95-3) is a high-purity fluorinated pyridine derivative with the molecular formula C₅H₅FN₂. This heterocyclic compound features an amino group at the 2-position and a fluorine substituent at the 3-position, making it a versatile building block for pharmaceutical, agrochemical, and materials science applications. With a purity of ≥97%, it is ideal for synthetic modifications, coupling reactions, and as a precursor for fluorinated heterocycles. The compound is supplied as a crystalline solid with excellent stability under standard storage conditions. Its unique electronic properties due to fluorine substitution enhance reactivity in nucleophilic aromatic substitution (S_NAr) and metal-catalyzed cross-coupling reactions. Strict quality control ensures batch-to-batch consistency for research and industrial use.

Properties

• CAS Number: 21717-95-3
• Complexity: 76.8
• IUPAC Name: 3-fluoropyridin-2-amine
• InChI: InChI=1S/C5H5FN2/c6-4-2-1-3-8-5(4)7/h1-3H,(H2,7,8)
• InChI Key: WWEINXQNCAWBPD-UHFFFAOYSA-N
• Exact Mass: 112.04367633
• Molecular Formula: C5H5FN2
• Molecular Weight: 112.10
• SMILES: C1=CC(=C(N=C1)N)F
• Topological: 38.9
• Monoisotopic Mass: 112.04367633
• Synonyms: 2-Amino-3-fluoropyridine, 21717-95-3, DTXSID60376470, DTXCID70327498, 623-218-3, 3-fluoropyridin-2-amine, 3-fluoro-pyridin-2-ylamine, MFCD04114135, 2-Pyridinamine, 3-fluoro-, fluoropyridimine, 3-fluoro-2-pyridylamine, 3-fluoro-pyridin-2ylamine, 3-Fluoropyridin-2-ylamine, 2-amino-3-fluoro-pyridine, SCHEMBL309925, SCHEMBL2067835, SCHEMBL3516896, SCHEMBL3949080, 3-FLUORO-2-PYRIDINAMINE, SCHEMBL11546397, SCHEMBL21598394, 2-Amino-3-fluoropyridine, 97%, WWEINXQNCAWBPD-UHFFFAOYSA-N, BBL100973, SBB051797, STL554767, AKOS005063882, AB17912, AC-1016, CS-W019868, PS-9249, SY002465, DB-008308, A2799, EN300-56061

2-Amino-3-fluoropyridine serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, including kinase inhibitors and antiviral agents. Its reactive amino group enables derivatization for drug discovery, while the fluorine atom improves metabolic stability in bioactive molecules. In agrochemistry, it is used to develop advanced crop protection compounds. The compound also finds utility in materials science for creating fluorinated ligands in catalysis and electronic materials.

Safety and Hazards

GHS Hazard Statements

• H302 (87.2%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (10.6%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (14.9%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (97.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (12.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (87.2%)
• Acute Tox. 4 (10.6%)
• Skin Irrit. 2 (14.9%)
• Eye Irrit. 2 (97.9%)
• STOT SE 3 (12.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.