Description

2-Amino-2-cyclopropylacetic acid hydrochloride (CAS: 1219429-81-8) is a high-purity organic compound with the molecular formula C₅H₁₀ClNO₂, widely utilized in pharmaceutical research, peptide synthesis, and medicinal chemistry. This hydrochloride salt derivative of cyclopropylglycine offers enhanced solubility and stability, making it ideal for laboratory applications requiring precise reactivity and controlled conditions. The compound features a cyclopropyl group attached to an aminoacetic acid backbone, providing unique steric and electronic properties for drug discovery and biochemical studies. Suitable for use as a chiral building block or intermediate, it is rigorously tested for purity (typically ≥95% by HPLC) and supplied in sealed packaging to ensure long-term integrity. Available in quantities ranging from milligrams to kilograms, it is packaged under inert conditions to prevent degradation.

Properties

• CAS Number: 1219429-81-8
• Complexity: 109
• IUPAC Name: 2-amino-2-cyclopropyl-acetic acid;hydrochloride
• InChI: InChI=1S/C5H9NO2.ClH/c6-4(5(7)8)3-1-2-3;/h3-4H,1-2,6H2,(H,7,8);1H
• InChI Key: XINWYOAHPNHZJF-UHFFFAOYSA-N
• Exact Mass: 151.0400063
• Molecular Formula: C5H10ClNO2
• Molecular Weight: 151.59
• SMILES: C1CC1C(C(=O)O)N.Cl
• Topological: 63.3
• Monoisotopic Mass: 151.0400063
• Synonyms: 2-amino-2-cyclopropylacetic acid hydrochloride, 835-450-4, 1219429-81-8, Amino(cyclopropyl)acetic acid HCl, DL-cyclopropylglycine HCl, 49607-02-5, AMINO-CYCLOPROPYL-ACETIC ACID HYDROCHLORIDE, 2-amino-2-cyclopropylacetic acid;hydrochloride, Cyclopropaneacetic acid, alpha-amino-, hydrochloride (1:1), 2-Amino-2-cyclopropylaceticacidhydrochloride, 2-Amino-2-cyclopropaneacetic acid hydrochloride, amino(cyclopropyl)acetic acid hydrochloride, 2-AMINO-2-CYCLOPROPYLACETIC ACID HCL, MFCD09878802, SCHEMBL17423095, UYB42981, AKOS015848201, AS-37452, DB-061999, CS-0171561, EN300-73945, Z1273089257

2-Amino-2-cyclopropylacetic acid hydrochloride is primarily employed as a key intermediate in the synthesis of chiral pharmaceuticals and bioactive peptides. Its cyclopropyl moiety enhances conformational rigidity, making it valuable for probing enzyme-substrate interactions or designing protease inhibitors. Researchers also use it to modify peptide backbones in drug development, particularly for neurological and antimicrobial agents. The compound’s stability under acidic conditions further supports its utility in solid-phase peptide synthesis (SPPS).

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.