Description

2-(5-Chlorothiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS No. 635305-24-7) is a high-purity boronic ester derivative extensively utilized in pharmaceutical research, material science, and organic synthesis. With the molecular formula C₁₀H₁₄BClO₂S, this compound serves as a critical intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds in complex molecular architectures. Its pinacol boronic ester group enhances stability and reactivity, making it ideal for applications requiring controlled functionalization of thiophene scaffolds. This product is rigorously tested to ensure >98% purity (HPLC/GC), and is supplied in moisture-resistant packaging to maintain integrity. Suitable for researchers and industrial scientists working on heterocyclic chemistry, catalysis, and drug discovery.

Properties

• CAS Number: 635305-24-7
• Complexity: 244
• IUPAC Name: 2-(5-chloro-2-thienyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• InChI: InChI=1S/C10H14BClO2S/c1-9(2)10(3,4)14-11(13-9)7-5-6-8(12)15-7/h5-6H,1-4H3
• InChI Key: DDDRRTOIHWNUSI-UHFFFAOYSA-N
• Exact Mass: 244.0496087
• Molecular Formula: C10H14BClO2S
• Molecular Weight: 244.55
• SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC=C(S2)Cl
• Topological: 46.7
• Monoisotopic Mass: 244.0496087
• Synonyms: 635305-24-7, 2-(5-chlorothiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, DTXSID50438612, DTXCID10389434, 825-933-8, 5-Chlorothiophene-2-boronic acid pinacol ester, 5-Chloro-2-thiopheneboronic Acid Pinacol Ester, MFCD08063140, 2-(5-chloro-2-thienyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, 5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene, 1,3,2-Dioxaborolane, 2-(5-chloro-2-thienyl)-4,4,5,5-tetramethyl-, SCHEMBL5892452, DDDRRTOIHWNUSI-UHFFFAOYSA-N, AKOS015950082, GS-5836, MB05327, AC-33467, SY022332, C3301, CS-0153849, EN300-156335, H10061, Z1395078108, 2-(5-Chlorothiophen-2-yl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane, 2-(5-Chlorothiophen-2-yl)-4 pound not4 pound not5 pound not5-tetramethyl-1 pound not3 pound not2-dioxaborolane

This compound is widely used as a key synthetic intermediate in the preparation of bioactive molecules, particularly in the development of pharmaceuticals targeting neurological and oncological disorders. Its stability and reactivity make it invaluable for Suzuki-Miyaura cross-coupling reactions to construct conjugated systems in materials science. Researchers also employ it in the synthesis of advanced polymers and ligands for catalytic systems.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Dam. 1 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.